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Colorado vs Florida picks, predictions, odds: Who wins March Madness NCAA Tournament game?

No. 10 seed Colorado and No. 7 seed Florida play Friday, March 22 in an NCAA Tournament first-round game in Indianapolis, Indiana.

The South Region game is scheduled for 1:30 p.m. PT and can be seen on TBS (stream with Sling TV).

Who will win the March Madness game and advance to the second round?

Check out these NCAA Tournament first-round picks and predictions for the men's college basketball matchup.

Florida is a 1.5-point favorite in the game in March Madness odds provided by BetMGM Sportsbook. The Gators are -120 on the moneyline. The Buffaloes  are +100. The over/under for the game is set at 160.5 points.

Thursday's March Madness picks, predictions: Michigan State vs Mississippi State | Duquesne vs BYU | Akron vs Creighton | Long Beach State vs Arizona | Morehead State vs. Illinois | Oregon vs South Carolina | Nevada vs Dayton | Oakland vs Kentucky | McNeese vs Gonzaga | South Dakota State vs Iowa State | Saint Peter's vs Tennessee | NC State vs Texas Tech | Samford vs Kansas | Drake vs Washington State | Wagner vs North Carolina | Colorado State vs Texas

Friday's March Madness picks, predictions: Northwestern vs Florida Atlantic | Colgate vs Baylor | UAB vs San Diego State | Western Kentucky vs Marquette | Stetson vs UConn | New Mexico vs Clemson | Yale vs Auburn | Texas A&M vs Nebraska | Vermont vs Duke | Charleston vs Alabama | Longwood vs Houston | James Madison vs Wisconsin | TCU vs Utah State | Grand Canyon vs Saint Mary's | Colorado vs Florida | Grambling State vs. Purdue

Coloradoan.com: Colorado 74, Florida 67

Scott Proctor writes: "The Buffs were able to advance against a strong Boise State squad despite Simpson (6-for-18 shooting) not playing his best offensive game and J'Vonne Hadley and Cody Williams combining to shoot 0-for-7 from the field. Simpson will rise to the challenge that Clayton Jr. presents and Hadley (or Williams) won't go scoreless again. Colorado beats Florida 74-67."

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Gainesville Sun: Florida 76, Colorado 66

Kevin Brockway writes: "The Buffaloes will run out gas in the second half as UF's quick, high-powered backcourt of Zyon Pullin, Walter Clayton Jr. and Will Richard will be too much for Colorado to handle defensively."

March Madness predictions: ESPN game predictor's NCAA Tournament picks, win probabilities

Will Colorado basketball beat Florida in the NCAA Tournament? March Madness picks, predictions and odds weigh in on the first-round game.
Will Colorado basketball beat Florida in the NCAA Tournament? March Madness picks, predictions and odds weigh in on the first-round game.

Sportsbook Wire: Colorado 79, Florida 77

It writes: "Florida has won 16 games against the spread this season, while failing to cover or pushing 19 times. Colorado has won 17 games against the spread this year, while failing to cover or pushing 18 times. The Gators put up 85.1 points per game, 14.4 more points than the 70.7 the Buffaloes give up."

March Madness TV schedule: Television channels, streaming, how to watch NCAA Tournament

Sporting News: Bet Florida to beat Colorado in NCAA Tournament

David Suggs writes: "Nevertheless, Florida's productivity is hard to deny. Couple that with its impressive showings against top-tier opponents — the Gators took part in 14 matchups against Quad 1 teams, five more than the Buffaloes — and it's hard to look past Golden's bunch, especially against a streaky bubble team like Colorado."

March Madness game odds: Point spreads, moneylines, over/unders for NCAA Tournament 2024

ESPN: Florida has a 62.5% chance to beat Colorado in March Madness

The site gives the Buffaloes a 37.5% shot at defeating the Gators in Friday's first-round March Madness NCAA Tournament game.

March Madness NCAA Tournament odds: Who is favored to win 2024 national championship?

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STREAM THE GAME: Watch Colorado vs. Florida live with Sling TV

BEST BETS: These are the best Arizona college basketball betting sites

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Colorado vs Florida March Madness NCAA Tournament picks, predictions