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San Diego State vs UConn Sweet 16 picks, predictions, odds: Who wins March Madness game?

No. 5 seed San Diego State and No. 1 seed UConn play Thursday, March 28 in an NCAA Tournament Sweet 16 game in Boston, Massachusetts.

The East Region game is scheduled for 4:39 p.m. PT and can be seen on TBS/truTV (stream with Sling TV).

Who will win the March Madness game and advance to the Elite 8? Check out these Sweet 16 picks and predictions for the men's college basketball matchup.

UConn is a 9.5-point favorite in the game in March Madness odds provided by BetMGM Sportsbook. The Huskies are -600 on the moneyline. The Aztecs are +425. The over/under for the game is set at 135.5 points.

San Diego State defeated No. 13 seed Yale in the second round, 85-57. UConn beat No. 9 seed Northwestern, 75-58.

Sweet 16 picks, predictions: Clemson vs Arizona | San Diego State vs UConn | Alabama vs. North Carolina | Illinois vs Iowa State | NC State vs Marquette | Gonzaga vs Purdue | Duke vs Houston | Creighton vs Tennessee | Probabilities

Sportsbook Wire: UConn 75, San Diego State 68

It writes: "UConn is 24-12-0 ATS this season. San Diego State has won 14 games against the spread this season, while failing to cover 20 times. The 81.6 points per game the Huskies put up are 15.3 more points than the Aztecs give up (66.3)."

Sweet 16 March Madness schedule: Television channels, how to watch, stream

FOX Sports: UConn 76, San Diego State 68

It writes: "Per the spread and over/under, the implied score for the encounter is Huskies 72, Aztecs 63. The Huskies have an 82.9% chance to claim victory in this game per the moneyline's implied probability. The Aztecs hold a 21.3% implied probability to come out on top."

Dimers.com: UConn 72, San Diego State 63

It writes: "Our popular predictive analytics model gives Connecticut an 81% chance of defeating San Diego State. Our predicted final score has Connecticut winning 72-63. According to our model, San Diego State (+9.5) has a 52% chance of covering the spread, while the Over/Under total of 135.5 points has an equal 50-50 chance of hitting."

Sweet 16 March Madness game odds: Point spreads, moneylines, over/unders

College Football News: UConn 82, San Diego State 67

Pete Fiutak writes: "It gets lost in the national championship loss last year that San Diego State fought its way back and was right there in it in the second half, and then … kaboom. UConn turned it up a few notches, San Diego State missed a few shots, national title Huskies. Can San Diego State somehow keep the score down into the 60s? The Aztecs allow 66.5 points per game, allowed 67 points or fewer 18 times - going 16-2 - and UConn is 2-3 when scoring fewer than 67 points. UConn will score more than 67 points. This will be closer than everyone will think … for 15 minutes.  UConn is too big, too explosive, and too good."

ESPN: UConn has an 86.2% chance to beat San Diego State in March Madness

The site gives the Aztecs a 13.8% shot at defeating the Huskies in the Sweet 16 March Madness NCAA Tournament game.

Sweet 16 March Madness odds: Who is favored to win national championship?

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STREAM THE GAME: Watch San Diego State vs. UConn live with Sling TV

BEST BETS: These are the best Arizona college basketball betting sites

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: San Diego State vs UConn Sweet 16 NCAA Tournament picks, predictions