Encarnacion didn't play Saturday, and the team sent him back to Cleveland to be examined by hand specialist Dr. Thomas Graham before deciding to shut him down ahead of the playoffs.
"We're going to put Edwin on the disabled list," manager Terry Francona said. "He got his hand X-rayed and it came back actually really good, and clean. So we're pleased about that. There is some swelling in the bicep. It's not bad at all. I think between the wrist and the bicep, we just thought letting him come back and be Edwin made the most sense."
Encarnacion, 35, is batting .229 with 25 homers and 81 RBIs for Cleveland. He also has been nursing a bone bruise in his right hand over the past few weeks.
Infielder Yandy Diaz will be recalled from Triple-A Columbus to take Encarnacion's spot on the roster.
Cleveland ace Trevor Bauer got the win Saturday night, but had to exit the game early after he took a line drive off his right ankle.
"He's getting a precautionary X-ray," Francona said. " James thinks he just has a bruise. He got hit pretty hard. Just to cover everything, we'll get an X-ray, and he's doing that right now. But I think we feel like he is OK."
Bauer took a Jose Abreu liner off his right leg in the bottom of the seventh inning and then left the clubhouse to get the X-ray.
He tossed 6 1/3 innings with eight strikeouts against the White Sox, holding Chicago to two hits. Bauer is 12-6 on the season with 2.22 ERA, striking out 214 batters in 166 innings.
--Field Level Media