Los Angeles Rams at San Francisco 49ers picks, predictions, odds: Who wins NFL in Week 18?
The Los Angeles Rams and San Francisco 49ers play on Sunday, Jan. 7 at Levi's Stadium in a game on the NFL Week 18 schedule.
Which team will win the Week 18 NFL game?
Check out these NFL Week 18 picks and NFL Week 18 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with free trial from FUBO).
The 49ers are a 4-point favorite over the Rams in NFL Week 18 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -200 on the moneyline, while Los Angeles is +165.
The over/under (point total) is set at 41 points.
The Rams are coming off a 26-25 win against the New York Giants in their NFL Week 17 game.
The 49ers are coming off a 27-10 win against the Washington Commanders.
NFL Week 18 picks: Steelers at Ravens | Texans at Colts | Falcons at Saints | Browns at Bengals | Jaguars at Titans | Vikings at Lions | Jets at Patriots | Buccaneers at Panthers | Bears at Packers | Chiefs at Chargers | Eagles at Giants | Cowboys at Commanders | Broncos at Raiders | Rams at 49ers | Seahawks at Cardinals | Bills at Dolphins | Power rankings | Playoffs: AFC | NFC | Odds | TV
The Arizona Republic: Rams 24, 49ers 20
Jeremy Cluff writes: "The 49ers have locked up the No. 1 seed in the playoffs and the Rams have secured a playoff berth. Both of these teams might just try to avoid injury in this one."
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Bookies.com: Bet the Rams on the moneyline vs. 49ers in NFL Week 18
Bill Speros writes: "Sam Darnold vs. Carson Wentz? The Dream Week 18 matchup the NFL envisioned when it scheduled this one. Or not. The 49ers own the No. 1 seed, homefield, and a first-round bye in the NFC. They can make it a two-week bye here. The Niners are still banged up and need the extra week to get well. The Rams clinched a playoff spot in Week 17 with their 26-25 win over the Giants. LA holds hold the No. 6 seed in the NFC, is 6-1 since the bye, and has sped-up the post-Super Bowl rebuild by a full season."
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AFC playoff picture Week 18: Jaguars, Bills, Colts, Texans, Steelers in postseason hunt
Sports Betting Dime: 49ers 29.3, Rams 17.1
The site's formula predicts that the 49ers will win the NFL Week 18 game against the Rams.
NFL power rankings Week 18: Browns, Bills, Cowboys, Lions, Chiefs Super Bowl contenders?
ESPN: 49ers have a 72.1% chance to beat Rams on Sunday
The site gives the Rams a 27.6% shot at winning the Week 18 NFL game.
NFL Week 18 odds: Point spreads, moneylines, over/unders for betting on games
NFL Week 18 schedule: Television channels, how to watch, stream games
Pro Football Network: Odds favor 49ers in NFL Week 18 vs. Rams
Kyle Soppe writes: "The Rams’ cover rate since 2021 is 10.1 percentage points higher when an underdog than when favored. The 49ers have won nine straight regular-season games over the Rams (they’ve outscored the Rams 55-19 in the last two meetings that they hosted)."
STREAM THE GAME: Watch Rams at 49ers live with FUBO (free trial)
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Los Angeles Rams at San Francisco 49ers picks, odds for NFL Week 18
