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Jacksonville Jaguars at Tennessee Titans picks, predictions: Who wins NFL Week 18 game?

The Jacksonville Jaguars and Tennessee Titans play on Sunday, Jan. 7 at Nissan Stadium in a game on the NFL Week 18 schedule.

Which team will win the Week 18 NFL game?

Check out these NFL Week 18 picks and NFL Week 18 predictions for the game, which can be seen at 11 a.m. MST on CBS (stream with free trial from FUBO).

The Jaguars are a 5.5-point favorite over the Titans in NFL Week 18 odds for the game, courtesy of BetMGM Sportsbook.

Jacksonville is -250 on the moneyline, while Tennessee is +190.

The over/under (point total) is set at 40 points.

The Jaguars are coming off a 26-0 win against the Carolina Panthers in their NFL Week 17 game.

The Titans are coming off a 26-3 loss against the Houston Texans.

NFL Week 18 picks: Steelers at Ravens | Texans at Colts | Falcons at Saints | Browns at Bengals | Jaguars at Titans | Vikings at Lions | Jets at Patriots | Buccaneers at Panthers | Bears at Packers | Chiefs at Chargers | Eagles at Giants | Cowboys at Commanders | Broncos at Raiders | Rams at 49ers | Seahawks at Cardinals | Bills at Dolphins | Power rankings | Playoffs: AFC | NFC | Odds | TV

The Arizona Republic: Jaguars 24, Titans 14

Jeremy Cluff writes: "Win and the Jaguars are AFC South champions. If they can't beat the struggling Titans, they don't deserve to make the postseason."

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Bookies.com: Must-win game for Jaguars vs. Titans in NFL Week 18

Bill Speros writes: "The Jaguars got a break Sunday in facing onto-to-2024 Carolina Panthers at home. Jacksonville won 26-0 without Trevor Lawrence, who missed the first start of his career - high school, college, or pro. Lawrence should be back for this one in what is pretty much a must-win game for the Jags. This game could be the final Tennessee Waltz for Titans head coach Mike Vrabel, who has been on the hot seat all season."

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AFC playoff picture Week 18: Jaguars, Bills, Colts, Texans, Steelers in postseason hunt

Sports Betting Dime: Jaguars 19.9, Titans 12.7

The site's formula predicts that the Jaguars will win the NFL Week 18 game against the Titans.

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Will Trevor Lawrence and the Jacksonville Jaguars beat the Tennessee Titans on Sunday? NFL Week 18 picks, predictions and odds weigh in on the game.
Will Trevor Lawrence and the Jacksonville Jaguars beat the Tennessee Titans on Sunday? NFL Week 18 picks, predictions and odds weigh in on the game.

ESPN: Jaguars have a 69.4% chance to beat Titans on Sunday

The site gives the Titans a 30.3% shot at winning the Week 18 NFL game.

NFL Week 18 odds: Point spreads, moneylines, over/unders for betting on games

NFL Week 18 schedule: Television channels, how to watch, stream games

Pro Football Network: Odds favor Jaguars in NFL Week 18 vs. Titans

Kyle Soppe writes: "The Jags are seeking a fourth straight win over the Titans, something they’ve never done (they did, however, beat the “Oilers” in four straight during the late ’90s). The Titans are 7-2-1 ATS as a home underdog since the start of 2021, making them the third-best team in such spots (minimum five such games played)."

STREAM THE GAME: Watch Jaguars at Titans live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Jacksonville Jaguars at Tennessee Titans picks, odds for NFL Week 18