San Francisco 49ers at Cleveland Browns picks, predictions, odds: Who wins in NFL Week 6?
The San Francisco 49ers and Cleveland Browns play on Sunday, Oct. 15 at Cleveland Browns Stadium in a game on the NFL Week 6 schedule.
Which team will win the Week 6 NFL game?
Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with free trial from FUBO).
The 49ers are a 4.5-point favorite over the Browns in NFL Week 6 odds for the game.
San Francisco is -210 on the moneyline, while Cleveland is +170.
The over/under (point total) is set at 42 points.
The 49ers are coming off a 42-10 win against the Dallas Cowboys in their NFL Week 5 game.
The Browns are coming off a bye week after losing to the Baltimore Ravens in Week 4, 28-3.
NFL Week 6 picks: Broncos at Chiefs | Ravens at Titans | Commanders at Falcons | Vikings at Bears | Seahawks at Bengals | 49ers at Browns | Saints at Texans | Colts at Jaguars | Panthers at Dolphins | Patriots at Raiders | Lions at Buccaneers | Cardinals at Rams | Eagles at Jets | Giants at Bills | Cowboys at Chargers | Win probabilities | Odds | Schedule | Announcers | Power rankings
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The Arizona Republic: 49ers 27, Browns 17
Jeremy Cluff writes: "The Browns had their bye in Week 5, giving them an extra week to prepare for this game. It won't matter. The 49ers are just too good with Brock Purdy leading San Francisco's offense."
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Bookies.com: Take the 49ers to cover vs. Browns
Bill Speros writes: "The 49ers are the most-complete team in the NFL. They've dominated tough opponents and push-overs. The 49ers put Philadelphia and any potential Super Bowl opponent on notice by demolishing Dallas 42-10. The wounded Browns are coming off the bye. Cleveland QB Deshaun Watson is recovering from a shoulder injury. The 49ers vary their offense each week, so look for Christian McCaffrey to run wild. We grabbed the 49ers when this line opened preseason at San Francisco -1. It moved to -3 last week and -4.5 Monday."
NFL Week 6 predictions: ESPN matchup predictor's picks, win probabilities for games
Sports Betting Dime: 49ers 17.8, Browns 13.2
The site's formula predicts that the 49ers will win the NFL Week 6 game against the Browns.
NFL Week 6 odds: Point spreads, moneylines, over/unders for betting on games
ESPN: 49ers have a 66.1% chance to beat Browns on Sunday
The site gives the Browns a 33.6% shot at winning the Week 6 NFL game.
NFL Week 6 schedule: Television channels, how to watch, stream games
CBS Sports: Odds favor 49ers in NFL Week 6 game vs. Browns
Tyler Sullivan writes: "San Francisco just flexed its Super Bowl muscles on Sunday night with a blowout win over the Cowboys. Now, they are 4.5-point road favorites as they gear up for a trip to Cleveland after opening as a field goal favorite. The Niners are 4-1 ATS this season and have an NFL-best +99 point differential. The Browns were on bye last week and have a defense that, in theory, should give the 49ers offense fits. That said, this San Francisco unit has yet to score fewer than 30 points, so it'll be up to Deshaun Watson -- who was nursing an injured shoulder before the bye -- to keep pace."
STREAM THE GAME: Watch 49ers at Browns live with FUBO (free trial)
NFL Week 6 announcers: Television broadcasters, announcing crews for Week 6 NFL schedule
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: San Francisco 49ers at Cleveland Browns picks, odds for NFL Week 6
