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San Francisco 49ers vs. Chicago Bears picks, predictions: Who wins NFL Week 1 game?

The San Francisco 49ers and Chicago Bears play Sunday in a Week 1 NFL game.

Which team will get the victory?

Check out these NFL Week 1 picks and predictions for the game, which can be seen at 10 a.m. MST on Fox.

The 49ers are a 6.5-point favorite in the game.

NFL Week 1 picks, predictions:

CBS Sports: 49ers 28, Bears 17

Tyler Sullivan writes: "The 49ers should be looked at as a considerable favorite against Chicago. The Bears have a new head coach and a second-year quarterback that is lacking go-to weapons around him, so 2022 may be another down year as they continue this rebuild. San Francisco was also 8-4 ATS on the road in 2021."

Pro Football Network: 49ers 27, Bears 13

Jason Katz writes: "Unlike the aforementioned Jets, the Bears have done next to nothing to help their sophomore signal-caller. Fields’ WR1 is Darnell Mooney, and his WR2 and WR3 are Byron Pringle and Equanimeous St. Brown. The only wide receiver Chicago drafted was 25-year-old special teamer Velus Jones Jr. A touchdown is a heavy price to lay on the road, but I just have no confidence in the Bears this season."

NFL Week 1 odds:

Bookies.com: Take the under in 49ers vs. Bears game

Bill Speros writes: "The 49ers, Deebo Samuel, and Jimmy Garoppolo remain stuck with each other – at least as of this writing. The situation has not changed since early this offseason. The Bears hired Matt Eberfus as head coach. He brought in a new offensive and defensive coordinator. The 49ers reached the NFC title game before blowing a 10-point lead to the Rams. Samuel wants a trade while the Niners want to trade Jimmy G. Garoppolo continues to heal from offseason shoulder surgery and could well be moved once he is deemed fully healthy."

Fansided: Bears 23, 49ers 20

Matt Verderame predicts that Chicago will defeat San Francisco in Week 1 of the NFL season at home.

More: When does the NFL season start? Here's the Week 1 schedule and how to watch games on TV

Can Justin Fields and the Chicago Bears beat the San Francisco 49ers in their Week 1 NFL game?
Can Justin Fields and the Chicago Bears beat the San Francisco 49ers in their Week 1 NFL game?

Walter Football: Go with the 49ers vs. Bears in Week 1

It writes: "The 49ers are the play because the Bears are absolutely dreadful. I'll be shocked if they're not a bottom-three team this year."

ESPN: 49ers have a 72.4% chance to win

The site gives the Bears a 27.3% chance to pick up the victory in Week 1.

More: NFL power rankings before Week 1: Los Angeles Rams, Buffalo Bills open NFL season at top

More: Super Bowl 57 odds: Preseason betting odds for every NFL team to win 2022-2023 Super Bowl

WSN: Take the Bears with the points vs. 49ers

Mike Lukas writes: "The Chicago Bears new head coach Matt Eberflus is a 52-year old defensive specialist who should fit right in with that historically defensive powerhouse, now with two rookies starting in his secondary – SS Jaquan Brisker and CB Kyler Gordon – a young team QB’d by the 23-year old OSU alum Justin Fields who struggled there his rookie season, a born winner ready to win. The oddsmakers are giving the home team Chicago Bears almost a touchdown in this one, so take them to cover the spread even though the Niners will most likely win this one outright."

NFL Spin Zone: 49ers 30, Bears 21

Brendan Danaher writes: "Kyle Shanahan’s explosive offensive scheme will be too much for the Bears’ middling defense to handle. Justin Fields doesn’t have enough weapons to overwhelm the 49ers’ defense led by up-and-coming defensive coordinator DeMeco Ryans. As if the task wasn’t difficult enough the Bears also have a new head coach in Matt Eberflus. The Bears will be lucky to win more than six games this season and this won’t be one of them."

NFL's highest paid players in 2022:

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: San Francisco 49ers vs. Chicago Bears picks, predictions NFL Week 1