San Francisco 49ers at Jacksonville Jaguars predictions, odds: Who wins NFL Week 10 game?
The San Francisco 49ers and Jacksonville Jaguars play on Sunday, Nov. 12 at EverBank Stadium in a game on the NFL Week 10 schedule.
Which team will win the Week 10 NFL game?
Check out these NFL Week 10 picks and NFL Week 10 predictions for the game, which can be seen at 11 a.m. MST on FOX (stream with free trial from FUBO).
The 49ers are a 3-point favorite over the Jaguars in NFL Week 10 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -150 on the moneyline, while Jacksonville is +125.
The over/under (point total) is set at 44.5 points.
The 49ers are coming off a bye in NFL Week 9.
The Jaguars are also coming off a bye week.
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The Arizona Republic: 49ers 24, Jaguars 20
Jeremy Cluff writes: "Both of these teams had a week off to prepare for this game and it gave the 49ers a week off to recover from three straight losses. They will bounce back with a strong defensive effort."
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Bookies.com: Take the Jaguars with the points vs. 49ers
Bill Speros writes: "An intriguing matchup – potentially – between the No. 1 player taken in the 2020 NFL Draft and the final player chosen in the 2022 NFL Draft. QB Trevor Lawrence has lived up to the expectations he brought to the River City as the first pick three years ago. San Francisco sophomore QB Brock Purdy won 15 straight NFL regular-season starts. His team has since lost three straight. The Jaguars have won 5 in a row. And they're at home early against a West Coast team getting points. A good deal."
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Sports Betting Dime: 49ers 24, Jaguars 16.5
The site's formula predicts that the 49ers will win the NFL Week 10 game against the Jaguars.
NFL Week 10 odds: Point spreads, moneylines, over/unders for betting on games
ESPN: 49ers have a 56.2% chance to beat Jaguars on Sunday
The site gives the Jaguars a 43.5% shot at winning the Week 10 NFL game.
NFL Week 10 predictions: ESPN matchup predictor's picks, win probabilities for this week
CBS Sports: Odds favor 49ers in NFL Week 10 vs. Jaguars
Tyler Sullivan writes: "Both of these teams had byes in Week 9 and were on very different trajectories heading into the break. The Niners lost three in a row, while the Jaguars won five straight. Despite their recent play, San Francisco is a field-goal road favorite over Jacksonville this weekend. Not only that, but it jumped up to the key 3-point number after initially opening at 2.5. The Niners are 1-3 ATS on the road this season while the Jaguars are 1-2 ATS at home."
NFL Week 10 schedule: Television channels, how to watch, stream games
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STREAM THE GAME: Watch 49ers at Jaguars live with FUBO (free trial)
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: San Francisco 49ers at Jacksonville Jaguars picks, odds in NFL Week 10
