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Houston Texans at Indianapolis Colts picks, predictions, odds: Who wins NFL Week 18 game?

The Houston Texans and Indianapolis Colts play on Saturday, Jan. 6 at Lucas Oil Stadium in a game on the NFL Week 18 schedule.

Which team will win the Week 18 NFL game?

Check out these NFL Week 18 picks and NFL Week 18 predictions for the game, which can be seen at 6:15 p.m. MST on ABC, ESPN, ESPN+ and ESPN Deportes (stream with free trial from FUBO).

The Texans are a 1-point favorite over the Colts in NFL Week 18 odds for the game, courtesy of BetMGM Sportsbook.

Houston is -120 on the moneyline, while Indianapolios is +100.

The over/under (point total) is set at 47.5 points.

The Texans are coming off a 26-3 win against the Tennessee Titans in their NFL Week 17 game.

The Colts are coming off a 23-20 win against the Las Vegas Raiders.

NFL Week 18 picks: Steelers at Ravens | Texans at Colts | Falcons at Saints | Browns at Bengals | Jaguars at Titans | Vikings at Lions | Jets at Patriots | Buccaneers at Panthers | Bears at Packers | Chiefs at Chargers | Eagles at Giants | Cowboys at Commanders | Broncos at Raiders | Rams at 49ers | Seahawks at Cardinals | Bills at Dolphins | Power rankings | Playoffs: AFC | NFC | Odds | TV

The Arizona Republic: Texans 24, Colts 23

Jeremy Cluff writes: "The winner of this game gets a playoff berth and has a shot at the AFC South title. That both of these teams are in this situation is a surprise. Rookie C.J. Stroud will make a difference late."

NFL Week 18 picks, predictions: Bills, Steelers, Texans get wins, Packers, Seahawks upset

Bookies.com: Bet the Texans on the moneyline vs. Colts in NFL Week 18

Bill Speros writes: "We may need the ghost of Oppenheimer to figure out all the different scenarios and tiebreakers for the final AFC playoff spots. For the Texans, it's pretty simple. Win and you're in. Lose and you're out. The Colts get in with a win, and can still back in if they don't. But it gets complicated. From the bettor's perspective, this will be one of the most competitive games of the week. The Texans are tough on the road within the division, having won 7 straight. C.J. Stroud was healthy and dealing in Week 17. He's going to close out his Offensive Rookie of the Year campaign with a road win."

NFC playoff picture Week 18: Buccaneers, Packers, Seahawks, Saints, Vikings, Falcons alive

AFC playoff picture Week 18: Jaguars, Bills, Colts, Texans, Steelers in postseason hunt

Sports Betting Dime: Texans 24.5, Colts 22.4

The site's formula predicts that the Texans will win the NFL Week 18 game against the Colts.

NFL power rankings Week 18: Browns, Bills, Cowboys, Lions, Chiefs Super Bowl contenders?

Will C.J. Stroud and the Houston Texans beat the Indianapolis Colts on Saturday? NFL Week 18 picks, predictions and odds weigh in on the game.
Will C.J. Stroud and the Houston Texans beat the Indianapolis Colts on Saturday? NFL Week 18 picks, predictions and odds weigh in on the game.

ESPN: Colts have a 51.6% chance to beat Texans on Saturday

The site gives the Texans a 48% shot at winning the Week 18 NFL game.

NFL Week 18 odds: Point spreads, moneylines, over/unders for betting on games

NFL Week 18 schedule: Television channels, how to watch, stream games

Pro Football Network: Odds favor Colts in NFL Week 18 vs. Texans

Kyle Soppe writes: "The road team is 3-0-1 outright in the past four games in this series, scoring an average of 28.5 points per game in the process. Since 2021, the Colts have been the fifth-worst ATS team in divisional games (6-11)."

STREAM THE GAME: Watch Texans at Colts live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Houston Texans at Indianapolis Colts picks, odds for NFL Week 18 game