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Denver Broncos at Seattle Seahawks: Predictions, picks and odds for NFL Week 1 matchup

In the first Monday Night Football game of the 2022 NFL regular season, Russell Wilson's Denver Broncos will take a trip to Seattle to take on Pete Carroll and the Seahawks.

In his first game since being traded to Denver, veteran quarterback Russell Wilson takes on his former team in a prime-time showdown at 8:15 p.m. ET Monday. Can the new-look Broncos start the season off with a win? Can the rebuilding Seahawks, behind QB Geno Smith, pull off an upset at home and spoil Wilson's coming-home party?

Here's a look at the betting details and USA TODAY's NFL staff picks for the Broncos vs. Seahawks game:

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Lorenzo Reyes: Broncos 25, Seahawks 21

While Seattle is certainly the weaker team here, it is still a challenging place to play on the road and I think they’re being undervalued with Geno Smith at quarterback. Russell Wilson is a clear advantage, but I don’t think Denver covers.

Denver Broncos quarterback Russell Wilson (3) warms up prior to an NFL preseason football game against the Dallas Cowboys, Saturday, Aug. 13, 2022, in Denver. (AP Photo/Jack Dempsey)
Denver Broncos quarterback Russell Wilson (3) warms up prior to an NFL preseason football game against the Dallas Cowboys, Saturday, Aug. 13, 2022, in Denver. (AP Photo/Jack Dempsey)

Safid Deen: Broncos 27, Seahawks 10

Russell Wilson will feel the love from Seattle fans during pregame, but the 12th man will have no problems letting him know he’s the enemy once the game starts. Still, Wilson makes the Broncos better, while the Seahawks get a tough reminder how great they had it with him at quarterback.

Lance Pugmire: Broncos 27, Seahawks 10

Speaking of showcase games, doesn’t this one seem predetermined? Russell Wilson’s return to his “12s” should be a powerful, and triumphant, event given that he’s been replaced by career backup Geno Smith.

Jarrett Bell: Broncos 24, Seahawks 20

Nate Davis: Seahawks 17, Broncos 16

Tyler Dragon: Broncos 20, Seahawks 13

Parker Gabriel: Broncos 27, Seahawks 20

Mike Jones: Broncos 33, Seahawks 19

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This article originally appeared on USA TODAY: Denver Broncos at Seattle Seahawks predictions, picks for NFL Week 1