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Buffalo Bills at New England Patriots picks, predictions, odds: Who wins NFL Week 7 game?

The Buffalo Bills and New England Patriots play on Sunday, Oct. 22 at Gillette Stadium in a game on the NFL Week 7 schedule.

Which team will win the Week 7 NFL game?

Check out these NFL Week 7 picks and NFL Week 7 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with free trial from FUBO).

The Bills are an 8.5-point favorite over the Patriots in NFL Week 7 odds for the game.

Buffalo is -400 on the moneyline, while New England is +325.

The over/under (point total) is set at 42.5 points.

The Bills are coming off a 14-9 win against the New York Giants in their NFL Week 6 game.

The Patriots are coming off a 21-17 loss against the Las Vegas Raiders.

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The Arizona Republic: Bills 27, Patriots 17

Jeremy Cluff writes: "The Bills just have too much firepower for the Patriots, even when their offense isn't firing on all cylinders."

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Bookies.com: Take the Bills to cover vs. Patriots in NFL Week 7

Bill Speros writes: "Since Tom Brady headed South, the Patriots have dropped six of seven games against Buffalo. We locked on the Bills at -3.5 in the preseason. Ahh, thus were the days. At this number, it's hard not to back the Bills. The Patriots are terrible (1-5) and getting worse. Josh Allen will use this as a get-right game for Buffalo's offense. It struggled against the Giants before pulling out a 14-9 win Sunday night. Even after Sunday, the Bills are willing by an average margin of 15.8 points. Listen for the Boo Birds in Foxboro early and often."

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Sports Betting Dime: Bills 31.1, Patriots 2.8

The site's formula predicts that the Bills will win the NFL Week 7 game against the Patriots.

NFL Week 7 odds: Point spreads, moneylines, over/unders for betting on games this week

NFL Week 7 picks and predictions weigh in on Sunday's Buffalo Bills vs. New England Patriots game.
NFL Week 7 picks and predictions weigh in on Sunday's Buffalo Bills vs. New England Patriots game.

ESPN: Bills have an 82.2% chance to beat Patriots on Sunday

The site gives the Patriots a 17.7% shot at winning the Week 7 NFL game.

NFL Week 7 schedule: Television channels, how to watch, how to stream games

CBS Sports: Odds favor Bills in NFL Week 7 vs. Patriots

Tyler Sullivan writes: "Buffalo narrowly escaped a major upset at the hands of the Giants on Sunday night, fending off what would have been a game-winning touchdown by Tyrod Taylor at the goal line in the final second of regulation. The Bills have been a mediocre bet so far this season with a 3-3 ATS record, but are 8.5-point road favorites as they're set to travel to Foxborough for a division matchup against the Patriots. New England dropped to 1-5 (SU and ATS) on the season with their loss to the Raiders. Bill Belichick's team is 0-3 ATS at home this season while the Bills are 1-1 ATS as a road favorite."

STREAM THE GAME: Watch Bills at Patriots live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Buffalo Bills at New England Patriots predictions, odds for NFL Week 7