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Tampa Bay Buccaneers at New Orleans Saints predictions, odds: Who wins NFL Week 4 game?

The Tampa Bay Buccaneers and New Orleans Saints play on Sunday, Oct. 1 at Caesars Superdome in New Orleans in a game on the NFL Week 4 schedule.

Which team will win the Week 4 NFL game?

Check out these NFL Week 4 picks and predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with free trial from FUBO).

The Saints are a 3-point favorite over the Buccaneers in NFL Week 4 odds for the game.

New Orleans is -160 on the moneyline, while Tampa Bay is +135.

The over/under (point total) is set at 40.5 points.

The Buccaneers are coming off a 25-11 Monday Night Football game loss against the Philadelphia Eagles in NFL Week 3.

The Saints are coming off an 18-17 loss against the Green Bay Packers in their third game of the 2023 NFL season.

NFL Week 4 picks: Lions at Packers | Falcons at Jaguars | Dolphins at Bills | Vikings at Panthers | Broncos at Bears | Ravens at Browns | Steelers at Texans | Rams at Colts | Buccaneers at Saints | Commanders at Eagles | Bengals at Titans | Raiders at Chargers | Patriots at Cowboys | Cardinals at 49ers | Chiefs at Jets | Seahawks at Giants

The Arizona Republic: Saints 20, Buccaneers 17

Jeremy Cluff writes: "The NFC South is one of the more interesting divisions in the NFL this season and both of these teams figure to be right in the race for the title. The Saints have the edge in a defensive struggle in New Orleans in this one."

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Bookies.com: Take the under in Saints vs. Buccaneers NFL Week 4 game

Bill Speros writes: "The Saints are probably disappointed Tom Brady retired. They beat Brady both in New Orleans and in Tampa Bay when he quarterbacked the Bucs. The Saints blew a 17-0 lead at Green Bay and may have lost Derek Carr in the process. Tampa Bay is looking to go 3-0 ATS and straight-up behind Baker Mayfield Monday night. This game could be a let-down of sorts for the Bucs hitting the road after a mega-Monday night showdown at Ray-Jay against Philly. This line has already tightened a point from New Orleans -4 to -3. No matter. We're staying in our safe space."

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Sports Betting Dime: Buccaneers 14.4, Saints 10

The site's formula predicts that the Buccaneers will win the NFL Week 4 game against the Saints.

NFL Week 4 schedule: Television channels, how to watch, stream games

Will the New Orleans Saints beat the Tampa Bay Buccaneers in their NFL Week 4 game? NFL Week 4 picks and predictions weigh in.
Will the New Orleans Saints beat the Tampa Bay Buccaneers in their NFL Week 4 game? NFL Week 4 picks and predictions weigh in.

ESPN: Saints have a 53.4% chance to beat Buccaneers on Sunday

The site gives the Buccaneers a 46.2% shot at winning the Week 4 NFL game.

NFL Week 4 odds: Point spreads, moneylines, over/unders for betting on games

CBS Sports: Odds favor Buccaneers in NFL Week 4 game vs. Saints

Tyler Sullivan writes: "The Bucs still have their Week 3 matchup in front of them on Monday night, but the big question for this game will be the status of Derek Carr, who left Sunday's loss to the Packers with a shoulder injury. He was taken to a local hospital and is believed to have suffered an AC joint sprain. If he is out for Week 4, that'd trust Jameis Winston in as the Saints starter and would almost certainly change the line in some capacity as it currently sits at Saints -3. Last year, the Bucs swept the season series against New Orleans."

STREAM THE GAME: Watch Buccaneers vs. Saints live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Tampa Bay Buccaneers at New Orleans Saints picks, odds for NFL Week 4