San Francisco 49ers at Pittsburgh Steelers predictions, odds: Who wins NFL Week 1 game?
The San Francisco 49ers and Pittsburgh Steelers play on Sunday, Sept. 10 in an NFL Week 1 game at Acrisure Stadium in Pittsburgh.
Which team will win the game?
Check out these NFL picks, predictions and odds for the game, which can be seen at 10 a.m. MST on FOX.
The 49ers are a 2.5-point favorite over the Steelers in the game.
San Francisco is -138 on the moneyline, while Pittsburgh is +118.
The over/under (point total) is set at 40.5.
The 49ers are coming off a 13-4 regular season in 2022 and an appearance in the NFC Championship Game in the NFL Playoffs.
The Steelers went 9-8 last season.
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Bookies.com: Bet the Steelers on the moneyline vs. 49ers
Bill Speros writes: "Brock Purdy beat Trey Lance for the QB 1 spot. Lance was shipped to Dallas. Oddsmakers have the 49ers are the No. 2 pick in the NFC. Neither potential starting QB has started more 10 NFL games. The 49ers are stacked at the necessary offensive skill positions and are comfortable with Purdy. The Steelers are riding with rookie Kenny Pickett at QB. He was ranked 28th among all starting NFL QBs by CBS Sports in the preseason. This one is going to be a rock fight. The Steelers have bigger rocks."
Pro Football Network: Take the Steelers to cover against 49ers
It writes: "The Steelers are a covering machine under Mike Tomlin as underdogs; 51-27-3 ATS and 15-4-3 as home underdogs."
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Fansided: Steelers 23, 49ers 20
Sayre Bedinger writes: "I’m so fascinated by these two teams. On the one hand, you have Shanahan’s 49ers who score points by the boatload no matter who is playing QB. On the other hand, you have the Steelers who won seven of their last nine games last season averaging 18 points per game. This could be a defensive battle, and as good as the 49ers were last season — reaching the NFC Championship — I’m taking the Steelers at home given the 49ers’ uncertainty at QB."
WSN.com: Go with the Steelers with the points vs. 49ers
Grant Mitchell writes: "While the Niners had one of the strongest defenses in the NFL and got even stronger with the addition of defensive lineman Javon Hargrave, the Steelers could challenge them for that title this time around. They have two studs in T.J. Watt and Minkah Fitzpatrick, drafted Joey Porter Jr., the son of former Steelers legend Joey Porter, to start at corner, and added thumping linebacker Cole Holcomb. There is concern for San Fran’s quarterback position as Brock Purdy continues his rehab and Trey Lance is yet to impress as a starter. Pittsburgh QB Kenny Pickett looked solid in spots but needs to progress and make more impact plays for the Steelers to truly challenge for a division title."
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Betting Pros: 49ers won't cover against Steelers
It writes: "We’re getting a West Coast team, the 49ers, traveling to the Eastern Time Zone for an early game against the undervalued Steelers. Pittsburgh closed the 2022 season on a 7-2 run and ranked sixth in DVOA over that span, according to Football Outsiders. The Niners are tough, but their QB situation is unsettled, and I like getting plus money on Mike Tomlin’s team against a visitor making a cross-country trip."
Sports Betting Dime: 49ers 23, Steelers 6.8
The site's formula predicts that the 49ers will win the NFL Week 1 game against the Steelers.
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ESPN: 49ers have a 56.9% chance to beat Steelers
The site gives the Steelers a 42.8% shot at winning the Week 1 NFL game.
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This article originally appeared on Arizona Republic: San Francisco 49ers at Pittsburgh Steelers picks, odds for NFL Week 1
