San Francisco 49ers at Los Angeles Rams picks, odds: Who wins NFL Week 2 game?
The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 17 in an NFL Week 2 game at SoFi Stadium in Inglewood, California.
Which team will win the Week 2 NFL game?
Check out these NFL picks, predictions and odds for the game, which can be seen at 1:05 p.m. MST on FOX.
The 49ers are a 7-point favorite over the Rams in the game.
San Francisco is -300 on the moneyline, while Los Angeles is +240.
The over/under (point total) is set at 42.5.
The 49ers are coming of a 30-7 win against the Pittsburgh Steelers in their NFL Week 1 game.
The Rams are coming off a 30-13 win against the Seattle Seahawks in their season opener.
More NFL Week 2 picks: Vikings at Eagles | Packers at Falcons | Raiders at Bills | Ravens at Bengals | Seahawks at Lions | Colts at Texans | Chiefs at Jaguars | Bears at Buccaneers | Chargers at Titans | Giants at Cardinals | 49ers at Rams | Jets at Cowboys | Commanders at Broncos | Dolphins at Patriots | Saints at Panthers | Browns at Steelers
The Arizona Republic: 49ers 28, Rams 20
Jeremy Cluff writes: "The Rams really surprised in their Week 1 win over the Seahawks. A Week 2 win over the 49ers would be stunning."
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Bookies.com: Take the Rams with the points vs. 49ers in NFL Week 2
Bill Speros writes: "San Francisco is the second-favorite out of the NFC. Brock Purdy didn't surprise anyone when he and the 49ers thrashed the Steelers in Pittsburgh 30-7. Meanwhile, the underdog Rams shocked the Seahawks with a 30-13 win in Seattle. The Rams were 3-1 last year as home underdogs, that covered 60% of their overall victories. In Week 1, This line has moved from San Francisco -4.5 to -7 points. Despite the pro-49ers crowd expected at SoFi, we like the "home" team to cover here."
NFL Week 2 betting odds: Point spreads, moneylines, over/unders for games
Sports Betting Dime: 49ers 27.1, Rams 5
The site's formula predicts that the 49ers will win the NFL Week 2 game against the Rams.
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ESPN: 49ers have a 65.3% chance to beat Rams on Sunday
The site gives the Rams a 34.4% shot at winning the Week 2 NFL game.
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CBS Sports: Odds favor 49ers in NFL Week 3 game vs. Rams
Tyler Sullivan writes: "Both of these NFC West clubs dropped 30 points in their Week 1 wins and also pulled out the ATS victory as well. So far, Kyle Shanahan has the edge in this rivalry between himself and Rams head coach Sean McVay. Shanahan is 9-3 SU against McVay in their careers, which includes a season sweep a season ago."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: San Francisco 49ers at Los Angeles Rams picks, odds for NFL Week 2
