Pittsburgh Steelers at Cincinnati Bengals: Predictions, picks and odds for NFL Week 1 matchup

The Pittsburgh Steelers and Cincinnati Bengals kick off the 2022 NFL regular season with a pivotal AFC North matchup in Week 1.

The Steelers and head coach Mike Tomlin will go with Mitch Trubisky over rookie Kenny Pickett at quarterback in a daunting Week 1 tilt with the defending AFC champions.

MeanwhBurrow is back under center for the Bengals and looks to continue his dynamic-duo relationship with second-year receiver Ja'Marr Chase.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Steelers-Bengals game:

Steelers at Bengals odds, moneyline and over/under

• Spread: Bengals (-6.5)

• Moneyline: Bengals (-280); Steelers (+230)

• Over/under: 44.5

• More odds, injury info for Steelers vs. Bengals

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Lorenzo Reyes: Bengals 23, Steelers 20

People make a big deal about the Super Bowl loser’s curse and there is some historical data to back that. I think the bigger thing is that Pittsburgh, in my opinion, has a notable upgrade at quarterback with Mitchell Trubisky over last year’s version of Ben Roethlisberger. Cincinnati is still young and should shake off the noise about a hangover, but I don’t think the Bengals cover that line.

Safid Deen: Bengals 27, Steelers 17

Joe Burrow and the defending AFC champion Bengals won’t be sneaking up on anybody this season. They’re still loaded and have what it takes to make another deep run this year. They’ll easily handle the Steelers, whose QB situation doesn’t excite me one bit.

Lance Pugmire: Bengals 27, Steelers 17

Defending AFC champion Cincinnati waxed the Steelers by a combined 65-20 in their division clashes last season, and now Mitchell Trubisky is Pittsburgh’s quarterback. Also intriguing to watch how the Bengals’ overhauled offensive line fares here.

Jarrett Bell: Steelers 26, Bengals 24

Nate Davis: Bengals 27, Steelers 23

Tyler Dragon: Bengals 28, Steelers 20

Parker Gabriel: Bengals 28, Steelers 21

Mike Jones: Bengals 28, Steelers 20

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NFL Week 1 odds, predictions and picks

Bills vs. Rams | Saints vs. Falcons | Browns vs. Panthers | 49ers vs. Bears | Steelers vs. Bengals | Eagles vs. Lions | Colts vs. Texans | Patriots vs. Dolphins | Ravens vs. Jets | Jaguars vs. Commanders | Giants vs. Titans | Chiefs vs. Cardinals | Raiders vs. Chargers | Packers vs. Vikings | Buccaneers vs. Cowboys | Broncos vs. Seahawks

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This article originally appeared on USA TODAY: Cincinnati Bengals at Pittsburgh Steelers predictions, picks for NFL Week 1