The Rams will be without star quarterback Matthew Stafford after he entered concussion protocol and is dealing with a 'neck issue' this week. Third-string quarterback Bryce Perkins could draw the start against an aggressive Chiefs defense.
The Chiefs look to keep rolling behind Patrick Mahomes. The offense continues to find balance as rookie running back Isiah Pacheco expands his role. The Chiefs own the NFL's top offense and get a Rams defense allowing 22.7 points per game.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Rams vs. Chiefs Week 12 game:
Rams at Chiefs odds, moneyline and over/under
Spread: Chiefs (-15.5)
Moneyline: Chiefs (-1401); Rams (+750)
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NFL Week 12 odds, predictions and picks
Bills at Lions | Giants at Cowboys | Patriots at Vikings | Broncos at Panthers | Buccaneers at Browns | Ravens at Jaguars | Texans at Dolphins | Bears at Jets | Bengals at Titans | Falcons at Commanders | Chargers at Cardinals | Raiders at Seahawks | Rams at Chiefs | Saints at 49ers | Packers at Eagles | Steelers at Colts
Lorenzo Reyes: Chiefs 33, Rams 12
Teams have figured out that quick passes against the Rams defense neutralizes the pass rush. With Matthew Stafford in concussion protocol and the offense in shambles, this is a lost season for L.A. How will players respond? The track record this season suggests: not great.
Safid Deen: Chiefs 27, Rams 20
The last two Super Bowl champions meet in what would have been an amazing Super Bowl matchup last season. But this game won’t look like it on Sunday. Patrick Mahomes and the Chiefs will face a tough defense but have too much firepower offensively that the defending champion Rams don’t have without Cooper Kupp.
Lance Pugmire: Chiefs 35, Rams 10
No Cooper Kupp, no hope for the defending champions as Patrick Mahomes begins tightening his vision toward a No. 1 AFC seed.
Jarrett Bell: Chiefs 30, Rams 17
Nate Davis: Chiefs 30, Rams 10
Tyler Dragon: Chiefs 28, Rams 16
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This article originally appeared on USA TODAY: Los Angeles Rams at Kansas City Chiefs: Game predictions, picks, odds