Indianapolis Colts at Tennessee Titans: Predictions, picks and odds for NFL Week 7 matchup
Running back Derrick Henry and the Tennessee Titans (3-2) come off their bye week to host quarterback Matt Ryan's Indianapolis Colts (3-2-1) in a pivotal AFC South showdown.
Ryan, the NFL's second-leading passer this season, had a bounce-back performance in Week 6 and will look to keep the momentum going on the road. Meanwhile, Henry, Ryan Tannehill and the Tennessee offense hope to put their week of rest to good use in a game with big ramifications in the division. Sunday's kickoff is set for 1 p.m. ET from Nissan Stadium.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Colts vs. Titans Week 7 game:
Colts at Titans odds, moneyline and over/under
Spread: Titans (-2.5)
Moneyline: Titans (-140); Colts (+117)
Over/under: 41.5
WHAT TO WATCH:22 things to watch as Colts battle Titans for AFC South lead
COLUMN:In this weird Titans' season, something is about to give
NEW LIDS: The NFL has returned alternate helmets in 2022: Ranking all 13 from best to worst
NFL Week 7 odds, predictions and picks
Saints vs. Cardinals | Colts vs. Titans | Packers vs. Commanders | Falcons vs. Bengals | Browns vs. Ravens | Giants vs. Jaguars | Buccaneers vs. Panthers | Lions vs. Cowboys | Jets vs. Broncos | Texans vs. Raiders | Chiefs vs. 49ers | Seahawks vs. Chargers | Steelers vs. Dolphins | Bears vs. Patriots
Lorenzo Reyes: Titans 25, Colts 20
Coming off the bye, I love Tennessee in this spot. The Titans have slowly progressed, winning three in a row before their week off. I just don’t trust Indianapolis, which needed to come from behind to beat the Jaguars and still has turnover issues even though it had its first turnover-free game of the season.
Safid Deen: Titans 24, Colts 16
This game will come down to which star running back carries the load. And with Jonathan Taylor questionable with an ankle injury, I like Derrick Henry and the Titans to win at home.
Lance Pugmire: Colts 24, Titans 21
Matt Ryan rode the momentum of the comeback victory in Denver to another victory versus the Jaguars thanks to Michael Pittman Jr. And the flawed, but gritty, team’s hope now is that Jonathan Taylor returns from his ankle injury.
NFL WEEK 7 PICKS: Who wins Super Bowl 54 rematch in Bay Area?
32 THINGS: Bills bag Chiefs; 'Who Dey?' trumps 'Who Dat?'
IN-DEPTH: The NFL coaches project
NFL salaries: These are the highest-paid NFL players
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.
This article originally appeared on USA TODAY: Indianapolis Colts at Tennessee Titans: Game predictions, picks, odds
