The Seminoles ran for 406 yards and opened the season with a victory for the first time since 2016.
Ward (14 carries, 127 yards), Benson (11 carries, 105 yards) and Toafili (13 carries, 101 yards) led the ground attack, which featured six touchdowns. Ward had two TD runs, and Benson had a 41-yard TD as the Oregon transfer frequently racked up yards after contact.
Florida State scored on eight of its first nine drives. Jordan Travis, Toafili and Ward had TD runs as Florida State led 20-0 after the first quarter.
Travis completed 11 of 15 passes for 207 yards. Kentron Poitier had four receptions for 84 yards. Mycah Pittman also had four catches for 44 yards. Johnny Wilson hauled in a 51-yard grab that set up a touchdown.
Joe Mischler completed a 22-yard touchdown pass to Abdul Janneh in the third quarter for Duquesne. The Dukes capitalized off a short field after Ryan Webb intercepted a pass from Florida State backup Tate Rodemaker.
Florida State’s defense forced eight punts. The Seminoles had five pass break-ups, including two by safety Jammie Robinson.
Duquesne: The Dukes managed just 164 yards (3.5 yards per play).
Duquesne plays at Youngstown State on Saturday
Florida State plays LSU at New Orleans on Sunday, Sept. 4.