Dallas Cowboys at San Francisco 49ers picks, predictions, odds: Who wins NFL Week 5 game?
The Dallas Cowboys and San Francisco 49ers play on Sunday, Oct. 8 at Levi's Stadium in a game on the NFL Week 5 schedule.
Which team will win the Sunday Night Football game?
Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 5:20 p.m. MST on NBC and Telemundo (stream with free trial from FUBO).
The 49ers are a 3.5-point favorite over the Cowboys in NFL Week 5 odds for the game.
San Francisco is -175 on the moneyline, while Dallas is +145.
The over/under (point total) is set at 45.5 points.
The Cowboys are coming off a 38-3 win against the New England Patriots in their NFL Week 4 game.
The 49ers are coming off a 35-16 win against the Arizona Cardinals in their fourth game of the 2023 NFL season.
NFL Week 5 picks: Bears at Commanders | Jaguars at Bills | Texans at Falcons | Panthers at Lions | Titans at Colts | Giants at Dolphins | Saints at Patriots | Ravens at Steelers | Bengals at Cardinals | Eagles at Rams | Jets at Broncos | Chiefs at Vikings | Cowboys at 49ers | Packers at Raiders
The Arizona Republic: 49ers 27, Cowboys 23
Jeremy Cluff writes: "The game of the week. The Cowboys' defense is impressive, but the 49ers have Christian McCaffrey. We'll side with San Francisco."
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Bookies.com: Take the 49ers to cover against Cowboys in Week 5
Bill Speros writes: "This is a solid Sunday night matchup steeped in history and very relevant in the present. The 49ers have eliminated Dallas from the playoffs each of the past two seasons, including in the NFC Divisional Round last January. That game was a 19-12 rock fight. At least one team should hit 20 this time. San Francisco (4-0/3-1) has won 15 straight regular-season games. Brock Purdy, Christian McCaffrey, and the 49ers continue to wreck opposing defenses. The Cowboys (3-1/3-1) should be riding high after delivering Bill Belichick the worst loss of career as Patriots head coach. San Francisco stays unbeaten here. And grabs the cover at home."
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Sports Betting Dime: 49ers 18.5, Cowboys 18.4
The site's formula predicts that the 49ers will win the NFL Week 5 game against the Cowboys.
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ESPN: 49ers have a 54.3% chance to beat Cowboys on Sunday Night Football
The site gives the Cowboys a 45.3% shot at winning the Week 5 NFL game.
NFL Week 5 odds: Point spreads, moneylines, over/unders for betting on games
CBS Sports: Odds favor 49ers in NFL Week 5 game vs. Cowboys
Tyler Sullivan writes: "Both of these NFC clubs are coming off convincing double-digit wins in Week 4 and now enter what could be a playoff preview. The Niners are now laying the field goal with the hook after opening at -3. Both teams are 3-1 ATS on the year, but the Niners are 2-0 ATS at home. Under Kyle Shanahan, the 49ers are 19-16-1 ATS (54.3%) as a home favorite, which is the sixth-best cover percentage in the NFL over that stretch."
STREAM THE GAME: Watch Cowboys vs. 49ers live with FUBO (free trial)
NFL Week 5 predictions: ESPN matchup predictor's picks, win probabilities for games
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Dallas Cowboys at San Francisco 49ers predictions, odds for NFL Week 5
