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Arizona Cardinals at Denver Broncos: Predictions, picks and odds for NFL Week 15 matchup

Two teams toiling toward the bottom of the standings in their respective divisions, Kliff Kingsbury leads the Arizona Cardinals (4-9) on the road against Russell Wilson's Denver Broncos (3-10).

Wilson's injury status will be worth monitoring in this game, but it'll be a tough test nonetheless for the Denver offense against a strong Arizona defense. Meanwhile, DeAndre Hopkins, James Conner and Co. will look to overpower a stingy Broncos' defense. The game is scheduled to kick off Sunday at 4:05 p.m. ET from Empower Field at Mile High.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Cardinals vs. Broncos Week 15 game:

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NFL Week 15 odds, predictions and picks

49ers vs. Seahawks | Colts vs. Vikings | Ravens vs. Browns | Dolphins vs. Bills | Lions vs. Jets | Chiefs vs. Texans | Steelers vs. Panthers | Eagles vs. Bears | Falcons vs. Saints | Cowboys vs. Jaguars | Cardinals vs. Broncos | Patriots vs. Raiders | Titans vs. Chargers | Bengals vs. Buccaneers | Giants vs. Commanders | Rams vs. Packers

Lorenzo Reyes: Broncos 18, Cardinals 13

Don’t look now, but the Broncos have covered two in a row. This defense gives Denver a chance to keep things close. The Cardinals are a mess and, with Kyler Murray out the rest of the season, I love that this line is just below a field goal.

Nathaniel Hackett did not have much success in his lone season as Denver Broncos coach.
Nathaniel Hackett did not have much success in his lone season as Denver Broncos coach.

Safid Deen: Broncos 24, Cardinals 17

Two struggling teams meet and thankfully, there are other games on the schedule to watch. But I’ll take the Broncos in this one. Broncos starter Russell Wilson (concussion) may not be available, nor will Cardinals starter Kyler Murray (knee) be either. Give me the home team with two backup quarterbacks.

Richard Morin: Broncos 19, Cardinals 18

The Broncos have quietly improved down the stretch this season, but in a battle of backup quarterbacks, I'll take the superior Denver defense to pick up the win.

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This article originally appeared on USA TODAY: Arizona Cardinals at Denver Broncos: Game predictions, picks, odds