San Francisco 49ers at Carolina Panthers: Predictions, picks and odds for NFL Week 5 matchup

Coming off a short week, Jimmy Garoppolo's San Francisco 49ers hit the road to face Baker Mayfield and the Carolina Panthers.

Mayfield has struggled in his first season quarterbacking the Panthers, but can the former No. 1 overall pick find a spark in Week 5 at home? Meanwhile, Deebo Samuel, George Kittle and the 49ers look to pick up a crucial win on the road. Which team takes the win? The game is scheduled to kick off Sunday at 4:05 p.m. ET from Bank of America Stadium.

Here's a look at the betting details and USA TODAY's NFL staff picks for the 49ers vs. Panthers Week 5 game:

49ers at Panthers odds, moneyline and over/under

• Spread: 49ers (-6.5)

• Moneyline: 49ers (-280); Panthers (+230)

• Over/under: 39.5

• More odds, injury info for 49ers vs. Panthers

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NFL Week 5 odds, predictions and picks

Colts vs. Broncos | Giants vs. Packers | Falcons vs. Buccaneers | Bears vs. Vikings | Steelers vs. Bills | Lions vs. Patriots | Chargers vs. Browns | Seahawks vs. Saints | Texans vs. Jaguars | Titans vs. Commanders | Dolphins vs. Jets | 49ers vs. Panthers | Eagles vs. Cardinals

Lorenzo Reyes: 49ers 28, Panthers 13

San Francisco can be a mercurial play with Jimmy Garoppolo under center, but the Panthers may be the worst team in the entire league. Baker Mayfield hasn’t gotten into a rhythm and constantly has his passes batted down. This Niners defense should feast. And Matt Rhule’s job security keeps becoming more perilous.

Safid Deen: 49ers 28, Panthers 17

Jimmy Garoppolo and the 49ers defense, fresh off their win over the defending champion Rams on Monday night, go on the road and handle the struggling Panthers.

Lance Pugmire: 49ers 17, Panthers 16

The week’s lowest under (39.5) reveals little faith in Jimmy Garoppolo and Baker Mayfield, and the 49ers more stout defense likely paces the road victory.

Jarrett Bell: 49ers 24, Panthers 17

Nate Davis: 49ers 30, Panthers 13

Tyler Dragon: 49ers 27, Panthers 13

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• All players

• Quarterback

• Running back

• Wide receiver

• Tight end

• Tackle

• Guard

• Center

• Kickers

• Edge rusher

• Safety

• Cornerback

• Linebacker

• Interior defensive linemen

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This article originally appeared on USA TODAY: San Francisco 49ers at Carolina Panthers: Game odds, picks, predictions, picks, odds