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Denver Broncos at Kansas City Chiefs picks, predictions, odds: Who wins NFL Week 6 game?

The Denver Broncos and Kansas City Chiefs play on Thursday, Oct. 12 at Arrowhead Stadium in the first game on the NFL Week 6 schedule.

Which team will win the Thursday Night Football game?

Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 5:15 p.m. MST on Amazon Prime Video (stream on Amazon Prime Video).

The Chiefs are a 10.5-point favorite over the Broncos in NFL Week 6 odds for the game.

Kansas City is -550 on the moneyline, while Denver is +400.

The over/under (point total) is set at 50.5 points.

The Broncos are coming off a 31-21 loss against the New York Jets in their NFL Week 5 game.

The Chiefs are coming off a 27-20 win against the Minnesota Vikings.

NFL Week 6 picks: Broncos at Chiefs | Ravens at Titans | Commanders at Falcons | Vikings at Bears | Seahawks at Bengals | 49ers at Browns | Saints at Texans | Colts at Jaguars | Panthers at Dolphins | Patriots at Raiders | Lions at Buccaneers | Cardinals at Rams | Eagles at Jets | Giants at Bills | Cowboys at Chargers | Win probabilities | Odds | Schedule | Announcers | Power rankings

NFL Week 6 picks, predictions: Who wins Seahawks-Bengals, Cowboys-Chargers, other games?

The Arizona Republic: Chiefs 33, Broncos 17

Jeremy Cluff writes: "The Chiefs have benefitted from some controversial calls and no-calls in recent weeks. There won't be any controversy about their win over the Broncos."

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Bookies.com: Take the Chiefs to cover vs. Broncos

Bill Speros writes: "Sean Payton and Russell Wilson have yet to cover in 5 games this season. The Broncos were among the great unknowns heading into the season. They have disappointed on all fronts. The Chiefs were 3-5-1 ATS as home favorites last season. Not very impressive for a Super Bowl champion. They lost outright as home favorites in Week 5. This line has swelled from 7 to 10.5. But the Broncos have moved south of terrible. And the Chiefs may need a point differential as a potential tiebreaker in the AFC. There won't be any let-up here."

NFL Week 6 odds: Point spreads, moneylines, over/unders for betting on games

Sports Betting Dime: Chiefs 39.7, Broncos 11.6

The site's formula predicts that the Chiefs will win the NFL Week 6 game against the Broncos.

NFL Week 6 predictions: ESPN matchup predictor's picks, win probabilities for games

ESPN: Chiefs have an 84.9% chance to beat Broncos on Thursday Night Football

The site gives the Broncos a 15% shot at winning the Week 6 NFL game.

NFL Week 6 schedule: Television channels, how to watch, stream games

CBS Sports: Go with the over in Chiefs vs. Broncos game

Tyler Sullivan writes: "The big concern for this game was going to be the status of Travis Kelce as he suffered a non-contact ankle injury in the win over Minnesota. However, he was able to return to the game and even caught a touchdown, so there is a massive sigh of relief in that regard. Kansas City is 3-2 ATS this season, while the Broncos have yet to cover a road game this season. This total is the biggest on the slate and for good reason as Denver is allowing offenses to average 36.2 points against it per game. With that in mind, it's not surprising to see the Over sporting a 4-1 record in Broncos games this season."

STREAM THE GAME: Watch Broncos at Chiefs live with Amazon Prime Video

NFL Week 6 announcers: Television broadcasters, announcing crews for Week 6 NFL schedule

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Denver Broncos at Kansas City Chiefs predictions, odds for NFL Week 6