Buffalo Bills at Los Angeles Chargers picks, predictions, odds: Who wins NFL Week 16 game?
The Buffalo Bills and Los Angeles Chargers play on Saturday, Dec. 23 at SoFi Stadium in a game on the NFL Week 16 schedule.
Which team will win the Week 16 NFL game?
Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 6 p.m. MST on Peacock.
The Bills are a 13.5-point favorite over the Chargers in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.
Buffalo is -900 on the moneyline, while Los Angeles is +600.
The over/under (point total) is set at 42.5 points.
The Bills are coming off a 31-10 win against the Dallas Cowboys in their NFL Week 15 game.
The Chargers are coming off a 63-21 loss against the Las Vegas Raiders.
NFL Week 16 picks: Saints at Rams | Bengals at Steelers | Bills at Chargers | Colts at Falcons | Packers at Panthers | Browns at Texans | Lions at Vikings | Commanders at Jets | Seahawks at Titans | Jaguars at Buccaneers | Cardinals at Bears | Cowboys at Dolphins | Patriots at Broncos | Raiders at Chiefs | Giants at Eagles | Ravens at 49ers | Power rankings | Odds | Schedule
The Arizona Republic: Bills 27, Chargers 13
Jeremy Cluff writes: "The Bills have defeated the Kansas City Chiefs and Dallas Cowboys in consecutive weeks. They shouldn't slip up against a Justin Herbert-less Chargers."
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Bookies.com: Bet the under in Bills vs. Chargers game
Bill Speros writes: "That’s right. Peacock. You have about the same chance of finding this game on your big screen as the Chargers have of keeping this one within two scores. We've grown immune to 14-point road favorites this season (see: the 49ers). The Bills can just give the ball to James Cook and run clock for 60 minutes. We're leaning toward the under here. Thinking Bills 30-3."
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Sports Betting Dime: Bills 27.3, Chargers 16.4
The site's formula predicts that the Bills will win the NFL Week 16 game against the Chargers.
NFL Week 16 odds: Point spreads, moneylines, over/unders for betting on games
ESPN: Bills have an 81.7% chance to beat Chargers on Saturday
The site gives the Chargers an 18.2% shot at winning the Week 16 NFL game.
NFL Week 16 schedule: Television channels, how to watch, stream games this week
Pro Football Network: Take Bills to beat Chargers in NFL Week 16
David Bearman writes: "I do not expect the Chargers, who looked to have given up last week, to stop the Bills express. Buffalo might be one of the best teams in the AFC and continue fighting for their postseason lives. You also never know what a team will look like with an interim coach. Either way, the Bills should win here. Just a matter if you want to lay 13.5 on the road on the other side of the country or take a team that has given up."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: Buffalo Bills at Los Angeles Chargers picks, odds for NFL Week 16 game
