New York Giants at Philadelphia Eagles picks, predictions, odds: Who wins in NFL Week 16?

The New York Giants and Philadelphia Eagles play on Monday, Dec. 25 at Lincoln Financial Field in a game on the NFL Week 16 schedule.

Which team will win the Christmas Day game?

Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 2:30 p.m. MST on FOX and FOX Deportes (stream with free trial from FUBO).

The Eagles are a 10.5-point favorite over the Giants in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.

Philadelphia is -550 on the moneyline, while New York is +400.

The over/under (point total) is set at 43.5 points.

The Giants are coming off a 24-6 loss against the New Orleans Saints in their NFL Week 15 game.

The Eagles are coming off a 20-17 Monday Night Football loss against the Seattle Seahawks.

NFL Week 16 picks: Saints at Rams | Bengals at Steelers | Bills at Chargers | Colts at Falcons | Packers at Panthers | Browns at Texans | Lions at Vikings | Commanders at Jets | Seahawks at Titans | Jaguars at Buccaneers | Cardinals at Bears | Cowboys at Dolphins | Patriots at Broncos | Raiders at Chiefs | Giants at Eagles | Ravens at 49ers | Power rankings | Odds | Schedule

The Arizona Republic: Eagles 28, Giants 16

Jeremy Cluff writes: "The Eagles really need a win to help their playoff seeding, while the Giants are looking toward next year already."

NFL Week 16 picks, predictions: Predicting Ravens-49ers, Cowboys-Dolphins, other games Bet the Eagles to cover vs. Giants

Bill Speros writes: "Tommy DeVito got whacked by the Saints in Week 15. It looks like he won't be getting made, after all. The Eagles will need this game to keep pace in the NFC East and, if needed, the Wild Card. Jalen Hurts should be fully healthy at home. And Big Blue has lost 10 straight at the Linc. Santa won't be booed in Philly this year."

NFL power rankings Week 16: Buffalo Bills Super Bowl contender after Dallas Cowboys rout?

Sports Betting Dime: Eagles 34.1, Giants 7.9

The site's formula predicts that the Eagles will win the NFL Week 16 game against the Giants.

NFL Week 16 odds: Point spreads, moneylines, over/unders for betting on games

ESPN: Eagles have an 88% chance to beat Giants on Monday

The site gives the Giants an 11.9 % shot at winning the Week 16 NFL game.

NFL Week 16 schedule: Television channels, how to watch, stream games this week

Pro Football Network: Take Eagles to beat Giants in NFL Week 16

David Bearman writes: "We need to see how the Eagles rebound from their back-to-back losses to Dallas and San Fran when they play in Seattle on Monday night, but they still shouldn’t have any issues with the Giants here. Lots can change with Hurts questionable on Monday night, so we wait and see."

STREAM THE GAME: Watch Giants at Eagles live with FUBO (free trial)

We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. USA TODAY Network newsrooms operate independently, and this doesn’t influence our coverage.

WANNA BET? How to bet on NFL games in 2023

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside.

NFL's highest paid players in 2023: Quarterbacks | Running backs | Wide receivers | Tight ends | Cornerbacks | Safeties | Linebackers | O-linemen | D-linemen | Edge rushers | Highest paid players: Overall | By position | By team

Reach Jeremy Cluff at Follow him on X, formerly Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to today.

This article originally appeared on Arizona Republic: New York Giants at Philadelphia Eagles picks, odds for NFL Week 16