New York Giants at Arizona Cardinals picks, predictions, odds: Who wins NFL Week 2 game?

The New York Giants and Arizona Cardinals play on Sunday, Sept. 17 in an NFL Week 2 game at State Farm Stadium in Glendale, Arizona.

Which team will win the Week 2 NFL game?

Check out these NFL picks, predictions and odds for the game, which can be seen at 1:05 p.m. MST on FOX.

The Giants are a 5.5-point favorite over the Cardinals in the game.

New York is -210 on the moneyline, while Arizona is +170.

The over/under (point total) is set at 38.5.

The Giants are coming of a 40-0 loss against the Dallas Cowboys in their NFL Week 1 game.

The Cardinals are coming off a 20-16 loss against the Washington Commanders in their season opener.

More NFL Week 2 picks: Vikings at Eagles | Packers at Falcons | Raiders at Bills | Ravens at Bengals | Seahawks at Lions | Colts at Texans | Chiefs at Jaguars | Bears at Buccaneers | Chargers at Titans | Giants at Cardinals | 49ers at Rams | Jets at Cowboys | Commanders at Broncos | Dolphins at Patriots | Saints at Panthers | Browns at Steelers

The Arizona Republic: Giants 23, Cardinals 17

Jeremy Cluff writes: "The Giants were absolutely embarrassed by the Cowboys, 40-0. The Cardinals aren't as bad as people think, but really need Kyler Murray back at QB."

NFL Week 2 schedule: Television channels, how to watch games

Bookies.com: Take the Cardinals with the points vs. Giants in Week 2

Bill Speros writes: "Daniel Jones just wishes he was out until Week 4. Danny Dimes was drawn and quartered by the Cowboys in a 40-0 loss Sunday night. The Cardinals played Washington tough in Week 1 on the road and nabbed a back-door cover. We're looking for value and shifting to the home team."

NFL Week 2 betting odds: Point spreads, moneylines, over/unders for games

Sports Betting Dime: Giants 25.2, Cardinals 18.1

The site's formula predicts that the Giants will win the NFL Week 2 game against the Cardinals.

NFL power rankings Week 2: Buccaneers, Browns, Packers, Rams, Lions surprise in upset wins

ESPN: Giants have a 64.4% chance to beat Cardinals on Sunday

The site gives the Cardinals a 35.3% shot at winning the Week 2 NFL game.

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CBS Sports: odds favor Giants in NFL Week 2 game vs. Cardinals

Tyler Sullivan writes: "New York is coming off an embarrassing shutout loss to the Cowboys on Sunday Night Football in Week 1 where it was unable to get anything going offensively and coughed up the football multiple times. Despite that, the Giants are 5.5-point road favorites as they head to Arizona to face the Cardinals in Week 2. The Cards fell to the Commanders in Week 1 but were able to record the ATS win, losing by just four points after being a touchdown dog. Last season, the Giants covered 77.8% of their road games, which was the best cover rate in the NFL."

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: New York Giants at Arizona Cardinals picks, odds for NFL Week 2 game