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San Francisco 49ers at Philadelphia Eagles picks, predictions: Who wins NFL Week 13 game?

The San Francisco 49ers and Philadelphia Eagles play on Sunday, Dec. 3 at Lincoln Financial Field in a game on the NFL Week 13 schedule.

Which team will win the Week 13 NFL game?

Check out these NFL Week 13 picks and NFL Week 13 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with free trial from FUBO).

The 49ers are a 2.5-point favorite over the Eagles in NFL Week 13 odds for the game, courtesy of BetMGM Sportsbook.

San Francisco is -145 on the moneyline, while Philadelphia is +120.

The over/under (point total) is set at 46.5 points.

The 49ers are coming off a 31-13 win against the Seattle Seahawks in their NFL Week 12 game.

The Eagles are coming off a 37-34 win against the Buffalo Bills.

NFL Week 13 picks: Seahawks at Cowboys | Chargers at Patriots | Lions at Saints | Falcons at Jets | Cardinals at Steelers | Colts at Titans | Dolphins at Commanders | Broncos at Texans | Panthers at Buccaneers | Browns at Rams | 49ers at Eagles | Chiefs at Packers | Bengals at Jaguars | NFL power rankings | NFL odds | NFL schedule | NFL win probabilities | NFL playoff picture

The Arizona Republic: 49ers 24, Eagles 23

Jeremy Cluff writes: "With apologies to the Cowboys and Lions, these are the two best teams in the NFC. The Eagles have been living on the edge with all of their close wins. They won't be able to beat the Niners in a close game this week."

NFL Week 13 picks: Who wins Seahawks-Cowboys, Broncos-Texans, 49ers-Eagles, other games?

Bookies.com: Bet the Eagles with the points vs. 49ers

Bill Speros writes: "This week’s 'Game of the Year' features a rematch of last season’s NFC championship game. The Eagles knocked out Brock Purdy and the 49ers and earned a ticket to Super Bowl 57. If Purdy can stay ambulatory, the 49ers will contend. The Eagles defense was hidden from most of the nation until their Monday night win at Kansas City in Week 11. It was able to contain the Bills in the rain Sunday night. Two impressive backt-to-back wins in 6 days. The winning QB of this game will have the inside track for MVP honors. Jalen Hurts has taken a quantum leap in his development this season. The Eagles are on a heater against winning teams at the Linc, having won 11 straight. They're getting points here."

NFL power rankings Week 13: Eagles, Ravens, Chiefs, 49ers, Cowboys among big winners

Sports Betting Dime: 49ers 25.7, Eagles 17.2

The site's formula predicts that the 49ers will win the NFL Week 13 game against the Eagles.

NFL Week 13 odds: Point spreads, moneylines, over/unders for betting on games this week

Will Brock Purdy and the San Francisco 49ers beat the Philadelphia Eagles on Sunday? NFL Week 13 picks, predictions and odds weigh in on the game.
Will Brock Purdy and the San Francisco 49ers beat the Philadelphia Eagles on Sunday? NFL Week 13 picks, predictions and odds weigh in on the game.

ESPN: 49ers have a 55.6% chance to beat Eagles on Sunday

The site gives the Eagles a 44% shot at winning the Week 13 NFL game against the Niners.

NFL Week 13 schedule: Television channels, how to watch, stream games

CBS Sports: Odds favor 49ers vs. Eagles in NFL Week 13

Tyler Sullivan writes: "We have ourselves a potential NFC Championship preview on Sunday with the Eagles hosting the 49ers. San Francisco will have the rest advantage after playing on Thanksgiving and it appears momentum is shifting in their favor. After the Eagles opened as a 1.5-point favorite, the Niners are now favored by two points on the road. If this holds, Philly would be the first team with a record of 10-1 or better to be a home dog since the merger (excluding the final week of the season where teams rest starters). The 49ers have been a road favorite six times this season and are 3-3 ATS in those games."

NFL Week 13 predictions: ESPN matchup predictor's picks, win probabilities for this week

NFL playoff picture Week 13: Atlanta Falcons, Indianapolis Colts join postseason field

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STREAM THE GAME: Watch 49ers at Eagles live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: San Francisco 49ers at Philadelphia Eagles picks, odds for NFL Week 13