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Los Angeles Rams at Indianapolis Colts picks, predictions, odds: Who wins NFL Week 4 game?

The Los Angeles Rams and Indianapolis Colts play on Sunday, Oct. 1 at Lucas Oil Stadium in Indianapolis in a game on the NFL Week 4 schedule.

Which team will win the Week 4 NFL game?

Check out these NFL Week 4 picks and predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with free trial from FUBO).

The Colts are a 1-point favorite over the Rams in NFL Week 4 odds for the game.

Indianapolis is -110 on the moneyline, while Los Angeles is also -110.

The over/under (point total) is set at 45 points.

The Rams are coming off a 19-16 Monday Night Football game loss against the Cincinnati Bengals in NFL Week 3.

The Colts are coming off a 22-19 overtime win against the Baltimore Ravens in their third game of the 2023 NFL season.

NFL Week 4 picks: Lions at Packers | Falcons at Jaguars | Dolphins at Bills | Vikings at Panthers | Broncos at Bears | Ravens at Browns | Steelers at Texans | Rams at Colts | Buccaneers at Saints | Commanders at Eagles | Bengals at Titans | Raiders at Chargers | Patriots at Cowboys | Cardinals at 49ers | Chiefs at Jets | Seahawks at Giants

The Arizona Republic: Colts 24, Rams 23

Jeremy Cluff writes: "The Colts are interestingly 0-1 at home and 2-0 on the road. They can win their first game at home this week, whether it's Gardner Minshew or Anthony Richardson leading them."

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Bookies.com: Take the under in Colts vs. Rams NFL Week 4 game

Bill Speros writes: "The Colts are 1-point home favorites after opening as 1-point home underdogs. The status of Colts rookie QB Anthony Richardson remains uncertain due to a concussion. But Minshew Mania lives. More importantly, the Colts are 2-1 thanks to their emerging defense. The Rams will be traveling east on a short week after playing host to Cincinnati Monday night. No need to break the Enigma code here. Points will be at a premium. This total is too high."

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Sports Betting Dime: Rams 28.7, Colts 20.8

The site's formula predicts that the Rams will win the NFL Week 4 game against the Colts.

NFL Week 4 schedule: Television channels, how to watch, stream games

Will the Indianapolis Colts beat the Los Angeles Rams in their NFL Week 4? NFL Week 4 picks and predictions weigh in.
Will the Indianapolis Colts beat the Los Angeles Rams in their NFL Week 4? NFL Week 4 picks and predictions weigh in.

ESPN: Rams have a 53.5% chance to beat Colts on Sunday

The site gives the Colts a 46.1% shot at winning the Week 4 NFL game.

NFL Week 4 odds: Point spreads, moneylines, over/unders for betting on games

CBS Sports: Odds favor Colts in NFL week 4 game vs. Rams

Tyler Sullivan writes: "Indy was able to pull off the upset in Baltimore despite not having starting quarterback Anthony Richardson under center. His status will be worth monitoring as the week progresses, but the club has proven it can win with Gardner Minshew at the helm. The Colts are 2-1 ATS this year, but both of those victories have come on the road. As for the Rams, they'll need to get out of Cincinnati before looking at this matchup."

STREAM THE GAME: Watch Rams vs. Colts live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Los Angeles Rams at Indianapolis Colts picks, odds for NFL Week 4 game