According to NFL Network, New England's top wide receiver is accepting the ban following the denial of his appeal and has no plan to sue over the suspension.
He will be eligible to return Week 5 against the Indianapolis Colts. He can practice beginning Oct. 1, three days before the Thursday game against the Colts.
Various reports indicated Edelman's positive test was for a substance that was not immediately recognizable.
Edelman's suspension will keep him out of games at home against the Houston Texans, on the road against the Jacksonville Jaguars and Detroit Lions, and at home against the Miami Dolphins. He will forfeit approximately $471,000 of his $2 million base salary this year.
The 32-year-old apologized on Instagram for the positive test a day after news of it broke, writing, "I don't know what happened." He added that he has taken "many, many tests obviously over the course of my career, and nothing like this has ever happened."
Edelman's personal trainer, Alex Guerrero, released a statement the day before Edelman's apology defending the integrity of his facility, the TB12 Sports Therapy Center. Guerrero started the facility with Tom Brady and works with several Patriots players -- including Brady, Edelman and Rob Gronkowski -- a matter that has reportedly been a source of tension between Brady and head coach Bill Belichick.
Entering his 10th season, Edelman hasn't played since the team's Super Bowl LI victory in February 2017. He missed all of last season after tearing the anterior cruciate ligament in his right knee during a preseason contest.
He returned to the field during the Patriots' mandatory minicamp in June after previously attending voluntary organized team activities.
In nine NFL seasons, including last year's campaign that was wiped out by injury, Edelman has 425 receptions for 4,540 yards and 24 touchdowns. He made 98 grabs for 1,106 yards and three scores in 2016.
--Field Level Media