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Detroit Lions at Tampa Bay Buccaneers picks, predictions, odds: Who wins NFL Week 6 game?

The Detroit Lions and Tampa Bay Buccaneers play on Sunday, Oct. 15 at Raymond James Stadium in a game on the NFL Week 6 schedule.

Which team will win the Week 6 NFL game?

Check out these NFL Week 6 picks and NFL Week 6 predictions for the game, which can be seen at 1:25 p.m. MST on FOX (stream with free trial from FUBO).

The Lions are a 3-point favorite over the Buccaneers in NFL Week 6 odds for the game.

Detroit is -175 on the moneyline, while Tampa Bay is +145.

The over/under (point total) is set at 45.5 points.

The Lions are coming off a 42-24 win against the Carolina Panthers in their NFL Week 5 game.

The Buccaneers are coming off a bye week after beating the New Orleans Saints in Week 4, 26-9.

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The Arizona Republic: Buccaneers 27, Lions 24

Jeremy Cluff writes: "The Buccaneers had a bye week to rest up for this one. Baker Mayfield and Tampa Bay have impressed so far this season and will impress in a Week 6 thriller at home."

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Bookies.com: Take the Lions to cover vs. Buccaneers

Bill Speros writes: "The Buccaneers wear their very-cool, throw-back Creamsicle uniforms in Week 6. They lost their first 26 games in those threads back in 1976-77. Unlike the Patriots, the Buccaneers have shown there is life after Tom Brady. This duel of first-place teams proves it, having been flexed into the late FOX time slot. The Bucs and Baker Mayfield are 3-1 and lead the NFC South coming off the bye. The Lions have finally gelled into a division/playoff contender. The Lions continue to take advantage of a lack of consideration by oddsmakers and are 13-2 ATS in their past 15 games. The Bucs are built around their defense and not well equipped to play from behind. We will sweat the hook here."

NFL Week 6 predictions: ESPN matchup predictor's picks, win probabilities for games

Sports Betting Dime: Lions 17.9, Buccaneers 14.2

The site's formula predicts that the Lions will win the NFL Week 6 game against the Buccaneers.

NFL Week 6 odds: Point spreads, moneylines, over/unders for betting on games

ESPN: Lions have a 55.1% chance to beat Buccaneers on Sunday.

The site gives the Buccaneers a 44.6% shot at winning the Week 6 NFL game.

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CBS Sports: Odds favor Lions vs. Buccaneers in NFL Week 6

Tyler Sullivan writes: "No Gibbs? No St. Brown? No problem. Even with the Lions missing a couple of key pieces on offense, they were still able to drop 42 points in a win against the Panthers. That was large in part thanks to multiple turnovers forced by the defense and rookie Sam LaPorta catching two touchdowns. Detroit is now 4-1 ATS on the year and is a perfect 2-0 ATS on the road. It will now go to Tampa Bay to face a Bucs team that was on the bye in Week 5, but have been impressive throughout the first month and are 3-1 ATS. The Lions were able to cover their lone game this season as a road favorite and the Bucs did lose their only game as a home underdog."

STREAM THE GAME: Watch Lions at Buccaneers live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Detroit Lions at Tampa Bay Buccaneers predictions, odds for NFL Week 6