Cardinals now 2.5-point underdogs vs. 49ers

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The Arizona Cardinals are set to face the San Francisco 49ers Sunday afternoon for the second time this season. They enter the game with game-time decisions about the availability of quarterback Kyler Murray and receiver DeAndre Hopkins.

They began the week as 2.5-point favorites against San Francisco. Since then, though, the line has moved and the Cardinals are now underdogs for the fourth time this season.

According to Tipico Sportsbook, the 49ers are now -145 on the money line and -2.5 against the spread.

Murray and Hopkins were unable to practice all week. Murray sprained his ankle at the end of the Cardinals’ 24-21 loss to the Green Bay Packers in Week 8. Hopkins has a hamstring injury. Both are officially questionable for the game.

Their No. 2 receiver, A.J. Green, is also likely to miss the game, as he tested positive for COVID-19 early in the week.

Defensive end J.J. Watt has a shoulder injury that could cause him to miss the rest of the season.

The Cardinals, though, are 3-0 ATS and 3-0 overall when they are the underdogs.

The two teams kick off Sunday afternoon at 2:25 p.m. Arizona time (4:25 p.m. ET) at Levis Stadium in Santa Clara.

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J.J. Watt ruled out vs. 49ers; Kyler Murray, DeAndre Hopkins questionable

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