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Arizona Cardinals at Seattle Seahawks: Predictions, picks and odds for NFL Week 6 matchup

richard morin, usa today
·2 min read
4

Kyler Murray and the Arizona Cardinals (2-3) couldn't get a game-tying field goal in Week 5 and now limp into a road matchup against Geno Smith's Seattle Seahawks (2-3) in a game with huge NFC West implications.

Can Kliff Kingsbury's Cardinals pick up a road win, or will Seattle's Smith, who leads the NFL in quarterback rating, keep slinging it en route to a Week 6 win over Arizona? The game is scheduled to kick off Sunday at 4 p.m. ET from CenturyLink Field.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Cardinals vs. Seahawks Week 6 game:

Cardinals at Seahawks odds, moneyline and over/under

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Commanders vs. Bears | Patriots vs. Browns | Buccaneers vs. Steelers | Ravens vs. Giants | Vikings vs. Dolphins | Jets vs. Packers | 49ers vs. Falcons | Bengals vs. Saints | Jaguars vs. Colts | Cardinals vs. Seahawks | Panthers vs. Rams | Bills vs. Chiefs | Cowboys vs. Eagles | Broncos vs. Chargers

Lorenzo Reyes: Seahawks 33, Cardinals 27

Seattle has a surprisingly explosive offense and Geno Smith is one of the more efficient passers in the league right now. The Cardinals are still sorely missing DeAndre Hopkins, who is eligible to return after this week. I’m holding off on Arizona until then.

Seattle Seahawks quarterback Geno Smith avoids Detroit Lions safety DeShon Elliott (5) and runs into the end zone for a 8-yard touchdown run during the first half of an NFL football game, Sunday, Oct. 2, 2022, in Detroit. (AP Photo/Duane Burleson)
Seattle Seahawks quarterback Geno Smith avoids Detroit Lions safety DeShon Elliott (5) and runs into the end zone for a 8-yard touchdown run during the first half of an NFL football game, Sunday, Oct. 2, 2022, in Detroit. (AP Photo/Duane Burleson)

Safid Deen: Seahawks 24, Cardinals 21

Kyler Murray’s late mistake cost the Cardinals in their attempt to beat the undefeated Eagles last week. But give me Geno Smith and the pesky Seahawks in their first home game in two weeks.

Lance Pugmire: Cardinals 27, Seahawks 24

A tough injury loss of running back Rashaad Penny puts more pressure on revived Geno Smith, which means a likely air show aimed at D.K. Metcalf sand Tyler Lockett while Arizona appreciates the noisy break from home, where it has lost eight straight.

Jarrett Bell: Seahawks 24, Cardinals 23

Nate Davis: Cardinals 27, Seahawks 24

Tyler Dragon: Cardinals 24, Seahawks 20

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This article originally appeared on USA TODAY: Arizona Cardinals at Seattle Seahawks: Game predictions, picks, odds