Arizona Cardinals at San Francisco 49ers picks, predictions, odds: Who wins in NFL Week 4?
The Arizona Cardinals and San Francisco 49ers play on Sunday, Oct. 1 at Levi's Stadium in Santa Clara, California in a game on the NFL Week 4 schedule.
Which team will win the Week 4 NFL game?
Check out these NFL Week 4 picks and predictions for the game, which can be seen at 1:25 p.m. MST on FOX (stream with free trial from FUBO).
The 49ers are a 14-point favorite over the Cardinals in NFL Week 4 odds for the game.
San Francisco is -835 on the moneyline, while Arizona is +550.
The over/under (point total) is set at 42 points.
The Cardinals are coming off a 28-16 win against the Dallas Cowboys in their NFL Week 3 game.
The 49ers are coming off a 30-12 win against the New York Giants in their third game of the 2023 NFL season.
NFL Week 4 picks: Lions at Packers | Falcons at Jaguars | Dolphins at Bills | Vikings at Panthers | Broncos at Bears | Ravens at Browns | Steelers at Texans | Rams at Colts | Buccaneers at Saints | Commanders at Eagles | Bengals at Titans | Raiders at Chargers | Patriots at Cowboys | Cardinals at 49ers | Chiefs at Jets | Seahawks at Giants
The Arizona Republic: 49ers 24, Cardinals 17
Jeremy Cluff writes: "Where's the respect for the Cardinals? They are once again a huge underdog. Josh Dobbs and company may not pull off the upset this time, but they'll keep it close in San Francisco."
NFL Week 4 picks, predictions: Lions at Packers, Dolphins at Bills among must-see games
Bookies.com: Take the 49ers to cover against Cardinals in NFL Week 4
Bill Speros writes: "The Cardinals shocked the world with their 28-16 win over Dallas, winning outright as 12.5-point underdogs. Now that Jonathan Gannon's Cardinals have their win for the season, expect a sobering descent back into this Meta Verse at Levi's Stadium in Week 4. The 49ers and Dolphins have risen above the rest of the NFL in terms of 2023 Elite Status. San Francisco has the added bonus of being at home, coming off an extended layoff, and win over the Giants at home on Thursday in Week 3. This line has expanded from 9.5 (when we locked in Niners) to 14.5. Brock Purdy, Deebo Samuel, George Kittle and CMC should have it covered. Figuratively and literally."
NFL power rankings Week 4: Raising Arizona, dropping Dallas after Cardinals' shocking win
Sports Betting Dime: 49ers 22.7, Cardinals 0.2
The site's formula predicts that the 49ers will win the NFL Week 4 game against the Cardinals.
NFL Week 4 schedule: Television channels, how to watch, stream games
ESPN: 49ers have an 87% chance to beat Cardinals on Sunday
The site gives the Cardinals a 12.9% shot at winning the Week 4 NFL game.
NFL Week 4 odds: Point spreads, moneylines, over/unders for betting on games
CBS Sports: Odds favor 49ers in NFL Week 4 game vs. Cardinals
Tyler Sullivan writes: "The Arizona Cardinals pulled off the biggest upset of Week 3, slaying the Cowboys at home as a double-digit underdog. However, they face another tough challenge in the 49ers, who are laying 14 points in this game (the largest of Week 4). Arizona is 3-0 ATS on the season, while the Niners are 2-1 ATS (3-0 SU). Under head coach Kyle Shanahan, the 49ers have covered 52.9% of their games as a home favorite."
STREAM THE GAME: Watch Cardinals vs. 49ers live with FUBO (free trial)
We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. USA TODAY Network newsrooms operate independently, and this doesn’t influence our coverage.
NFL's highest paid players in 2023: Quarterbacks | Running backs | Wide receivers | Tight ends | Cornerbacks | Safeties | Linebackers | O-linemen | D-linemen | Edge rushers | Highest paid players: Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today.
This article originally appeared on Arizona Republic: Arizona Cardinals at San Francisco 49ers picks, odds for NFL Week 4
