The Buffalo Bills will probably be without starting offensive linemen Cordy Glenn and Kraig Urbik for this Sunday's game at the San Francisco 49ers, according to ESPN.com.
Both injuries occurred during the Bills' 52-28 loss to the New England Patriots on Sunday.
Left tackle Glenn injured an ankle in the third quarter and right guard Urbik sustained a high right ankle sprain. Neither player returned to the game.
"I've got to take it day by day," Urbik said on the team's website. "You can't help a guy falling on your leg. It's unfortunate that it's happened two of the last three years. So I'll be out this week and we'll see where it goes from there."
Without Glenn and Urbik, the Bills face a 49ers defense ranked fourth in the NFL in opponents' scoring and offensive yardage.