Colts missing two key defensive players, tackle vs. Titans

The Indianapolis Colts host the Tennessee Titans in NFL Week 5 action, and the winner gets at least a share of the AFC South lead (considering the whole division is 2-2).

Tennessee has won 5 straight games in this series, and 4 in a row at Lucas Oil Stadium. The Titans are 0-2 on the road this season, but the Colts are 0-2 at home.

A couple of players familiar to Indiana football fans are returning. Titans fourth-year receiver Nick Westbrook-Ikhine, who played at Indiana University, has 2 receiving touchdowns this season. Tenth-year defensive lineman Denico Autry played three years for the Colts (2018-20).

Will Jonathan Taylor play for the Colts?

Looks like it. Jonathan Taylor remains on the Physically Unable to Perform list, but he has been a full practice participant and discussed his situation with the media on Thursday.

Doyel's view: Taylor doesn't want to be here anymore and all but said it

Week 5 Colts injury report

Colts who are out for the game: LB Shaquille Leonard (groin), DE Kwity Paye (concussion), T Bernhard Raimann (concussion); questionable: RB Jonathan Taylor (ankle; he remains on PUP but was a full participant all week); full participation Friday: DT DeForest Buckner (back), DE Tyquan Lewis (knee), G Quenton Nelson (toe), TE Mo Alie-Cox (ankle), C Ryan Kelly (concussion).

The Colts get C Ryan Kelly (concussion) back after missing two weeks. CB Dallis Flowers for the the rest of the season.

Titans injury report

Titans who are out for the game: WR Treylon Burks (knee), LB Luke Gifford (hamstring), DT Teair Tart (toe), OT Nicholas Petit-Frere (suspension); limited participation Friday: DT Jeffery Simmons (ankle); full participation: RB Derrick Henry (rest), LB Denico Autry (groin), WR DeAndre Hopkins (rest), CB Elijah Molden (hamstring), WR Kyle Philips (knee), G Peter Skoronski (abdomen), TE Josh Whyle (ankle).

Anthony Richardson stats

The numbers don't look great, but he is already providing a jolt of excitement. In Week 4, he was 11-of-25 for 200 yards and 2 touchdowns, and he rushed for 56 yards and a TD. But he led a 23-point comeback against the Los Angeles Rams to force overtime. (Season: 56.9% completions, 479 yards, 3 TDs, 1 INT; 131 rushing yards, 4 TDs.)

Insider: What does adding Taylor to Richardson mean for the Colts?

As Ryan Tannehill goes, so go the Titans

The key Titans storyline this season is quarterback Ryan Tannehill's performance.

Ryan Tannehill's Titans career vs. the Colts: 6-1 record, 67.4% completions, 183 passing yards per game, 12 TDs, 4 INTs, sacked 17 times.

Derrick Henry vs. the Colts

In 14 games against Indianapolis, Henry has rushed for 1,287 yards (5.1 per carry) and 7 TDs. He also has 20 catches, and Tennessee is 8-6 in those games. He has topped 100 rushing yards in 6 of his past 7 matchups. (His numbers are generally better against the Houston Texans and Jacksonville Jaguars than the Colts.)

More: Why Derrick Henry has a custom-made Peyton Manning Colts jersey

NFL power rankings: Colts rise despite loss

Frank Schwab, Yahoo: 18th, up one place from last week

Jonathan Taylor is expected back at practice this week and we'll see what that means for the Colts' offense, but in the meantime let's watch Anthony Richardson make a throw that most NFL quarterbacks couldn't even dream of ...

Vinnie Iyer, Sporting News: 17th, up 7 spots

The Colts lost but looked great with Anthony Richardson doing it as they are now in a four-way tie for first and last in the AFC South. They also do well against the run and can still run with Richardson, Zack Moss, and soon, maybe, Jonathan Taylor. The pass defense is the major issue, though.

Dalton Miller, Pro Football Network: 14th, down 1 spot

(Anthony Richardson) has a long way to go as a passer. The passing attack may not be incredibly “efficient” with him from a completion percentage perspective, but they will be explosive. Shane Steichen is coaching to Richardson’s strengths, just as he did Justin Herbert as a rookie and Jalen Hurts as a young passer.

Walter Football: 15th, down 1 position

The Colts lost, but they have to feel optimistic about Anthony Richardson’s comeback. Richardson was terrific in the second half. It’s a shame we couldn’t see what he’d accomplish in overtime because he never had the ball.

Nate Davis, USA TODAY: 17th, up 2 places

They're off to a generally promising start. But how will that be impacted as attention invariably shifts to RB Jonathan Taylor (PUP/ankle), who's eligible to return to the team whenever Indy brass sign off … assuming trade talks are not resuscitated?

Colts odds vs. Titans

The Titans are 2.5-point favorites, according to BetMGM. The over/under is 43 total points. Moneyline: Colts +120, Titans -145.

Meet the reporters: Join IndyStar Colts Insiders Oct. 11 to discuss the team

Colts leaders

Anthony Richardson (56.9% completions, 479 yards, 3 TDs, 1 INT; 131 rushing yards, 4 TDs); Zack Moss (280 rushing yards, 4.2 per carry, 1 TD); Michael Pittman Jr. (26 catches, 245 yards, 1 TD); Josh Downs (17 catches, 158 yards); Zaire Franklin (57 tackles, 1.5 sacks); Matt Gay (6-of-7 FGs).

Titans leaders

Ryan Tannehill (62% completions, 788 yards, 2 TDs, 4 INTs); Derrick Henry (285 rushing yards, 3.9 per carry, 2 TDs); DeAndre Hopkins (18 catches, 216 yards); Nick Westbrook-Ikhine (12 catches, 134 yards, 2 TDs); Azeez Al-Shaair (32 tackles, 3 for loss; 2 passes defended); Nick Folk (10-of-10 FGs).

Colts news from IndyStar.com

‘Relentless pursuit to be great’: How Zaire Franklin grew into a leadership role with the Colts

Weak link?: Colts will choose between inexperienced CB options to replace injured starter

More: One year after heartbreak, Colts center Ryan Kelly, wife bring home twin boys

More: What Colts said about Shaq Leonard being on the sideline in second half

Titans news from Tennessean.com

Mixed bag on the O-line: Coach discusses Nicholas Petit-Frere's return

Welcome to the team: Hopkins has been exactly what the Titans needed

This article originally appeared on Indianapolis Star: Colts injury list, Jonathan Taylor's status for NFL Week 5 vs. Titans