San Francisco 49ers at Seattle Seahawks: Predictions, picks and odds for NFL Week 12 game
As America recovers from turkey and pie, watch the nightcap of the Thanksgiving slate with the San Francisco 49ers (7-3) heading north to face the Seattle Seahawks (6-4).
Things seem to be back to normal in San Francisco, as the 49ers followed up a big win in Jacksonville with another great performance against the Tampa Bay Buccaneers. Brock Purdy was statistically perfect while tossing three touchdowns, but the big concern coming in the win was the loss of All-Pro safety Talanoa Hufanga.
It was a frustrating day at SoFi Stadium on Sunday for Seattle. The Seahawks led the majority of the game against the Rams, only to lose in the final minutes. Not only was it a disappointing loss against Los Angeles, but injuries to Geno Smith and Kenneth Walker III are big concerns heading into the first matchup of the top teams in the NFC West.
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Seahawks vs. 49ers odds, moneyline, over/under
The 49ers are favorites to defeat the Seahawks, according to BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.
Spread: 49ers (-7)
Moneyline: 49ers (-350); Seahawks (+260)
Over/under: 43.5
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NFL Week 12 odds, predictions and picks
Lions vs. Packers | Cowboys vs. Commanders | Seahawks vs. 49ers | Jets vs. Dolphins | Falcons vs. Saints | Bengals vs. Steelers | Texans vs. Jaguars | Colts vs. Buccaneers | Giants vs. Patriots | Titans vs. Panthers | Cardinals vs. Rams | Broncos vs. Browns | Raiders vs. Chiefs | Eagles vs. Bills | Chargers vs. Ravens | Vikings vs. Bears
Lorenzo Reyes: 49ers 29, Seahawks 17
Seattle is simply far too inconsistent, having covered only two of its last six games. And with Geno Smith’s status a big question on a short week, I think the Niners cover here with some room to spare.
Tyler Dragon: 49ers 24, Seahawks 16
The 49ers travel to Seattle for a Thanksgiving nightcap. The 49ers seemed to have righted the ship after their three game losing streak. San Francisco’s core players are healthy and it’s having a positive effect on both sides of the football. Meanwhile, Seahawks QB Geno Smith suffered a triceps contusion and RB Kenneth Walker sustained an oblique injury in last week’s loss to the Rams. Smith is expected to play but Walker might miss a few weeks.
Safid Deen: 49ers 27, Seahawks 13
The Seahawks offense is battered with Geno Smith, Kenneth Walker and Tyler Lockett dealing with recent injuries. That’s bad news for the Seahawks with the 49ers at full strength again. San Francisco wins decisively.
Victoria Hernandez: 49ers 24, Seahawks 16
Lumen Field is one of the toughest environments in the NFL and the 49ers will be thankful that the Seahawks have so many injuries. San Francisco just lost Talanoa Hufanga to a torn ACL, but other key players are recovered from their injuries and they shouldn't have a problem getting the holiday win.
Jordan Mendoza: 49ers 26, Seahawks 16
The status of Geno Smith and Kenneth Walker III will be a big factor in this matchup. If they are good to go, Seattle has a chance. If not, it can be a long day for the Seahawks. Regardless, the 49ers are rolling right now, and they get another double-digit win to strengthen their lead in the division.
You can view the full list of USA TODAY's NFL expert predictions here.
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This article originally appeared on USA TODAY: San Francisco 49ers at Seattle Seahawks: Game predictions, picks, odds
