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New Orleans Saints at New England Patriots predictions, odds: Who wins NFL Week 5 game?

The New Orleans Saints and New England Patriots play on Sunday, Oct. 8 at Gillette Stadium in a game on the NFL Week 5 schedule.

Which team will win the Week 5 NFL game?

Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with free trial from FUBO).

The Patriots are a 1-point favorite over the Saints in NFL Week 5 odds for the game.

New England is -115 on the moneyline, while New Orleans is -105.

The over/under (point total) is set at 39 points.

The Saints are coming off a 26-9 loss against the Tampa Bay Buccaneers in their NFL Week 4 game.

The Patriots are coming off a 38-3 loss against the Dallas Cowboys in their fourth game of the 2023 NFL season.

NFL Week 5 picks: Bears at Commanders | Jaguars at Bills | Texans at Falcons | Panthers at Lions | Titans at Colts | Giants at Dolphins | Saints at Patriots | Ravens at Steelers | Bengals at Cardinals | Eagles at Rams | Jets at Broncos | Chiefs at Vikings | Cowboys at 49ers | Packers at Raiders

The Arizona Republic: Saints 20, Patriots 16

Jeremy Cluff writes: "Two struggling offenses square off, so this one might come down to which defense makes more plays. Give us the Saints."

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Bookies.com: Take the Patriots to cover against Saints in Week 5

Bill Speros writes: "The Patriots are coming off their worst loss of the Bill Belichick era, a 38-3 humiliation in Dallas. The Patriots' defense has been ravaged by injuries. Mac Jones is clueless. Derek Carr sputtered against the Bucs in his return. This is one of just four games in which the Patriots were betting favorites before the season began. The Patriots will deliver a mirage victory, giving false hope to a team in need a of a complete overhaul. A loss here, and things will get really interesting on Route 1."

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Sports Betting Dime: Saints 17.4, Patriots 9.1

The site's formula predicts that the Saints will win the NFL Week 5 game against the Patriots.

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Will Mac Jones and the New England Patriots beat the New Orleans Saints? NFL Week 5 picks and predictions weigh in on Sunday's game.
Will Mac Jones and the New England Patriots beat the New Orleans Saints? NFL Week 5 picks and predictions weigh in on Sunday's game.

ESPN: Patriots have a 53.9% chance to beat Saints on Sunday

The site gives the Saints a 45.7% shot at winning the Week 5 NFL game.

NFL Week 5 odds: Point spreads, moneylines, over/unders for betting on games

CBS Sports: Odds favor the under in Saints vs. Patriots NFL Week 5 game

Tyler Sullivan writes: "New England has reached a low point in its season after being blown out at the hands of the Cowboys in a game where Bill Belichick elected to bench Mac Jones. They'll now look to pick up the pieces as they head back to Foxborough to host a Saints team that also is struggling with an injured Derek Carr. Given where both of these offenses are at, it shouldn't be too surprising to see this game as the lowest total on the Week 5 slate. Through the first month, the Under is 7-1 between these two teams."

STREAM THE GAME: Watch Saints vs. Patriots live with FUBO (free trial)

NFL Week 5 predictions: ESPN matchup predictor's picks, win probabilities for games

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: New Orleans Saints at New England Patriots picks, odds for NFL Week 5