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Notre Dame vs. Louisville schedule: Odds, injury news and how to watch Week 6 game

The undefeated No. 25 Louisville Cardinals are headed home in Week 6 for a matchup with the No. 11 Notre Dame Fighting Irish.

Louisville receiver Jadon Thompson (2) and North Carolina State cornerback Aydan White (3) vie for a pass during the second half.
Louisville receiver Jadon Thompson (2) and North Carolina State cornerback Aydan White (3) vie for a pass during the second half.

Louisville moved into the Coaches' Poll top 25 after defeating North Carolina State to remain undefeated. Their 5-0 overall record and 3-0 conference record is the best in the ACC with No. 13 North Carolina and No. 5 Florida State close behind at 4-0 overall after their byes last week.

Quarterback Jack Plummer completed 21 of 35 pass attempts with 286 yards, one touchdown and two interceptions in the win over the Wolfpack.

Notre Dame stay on the road after managing to pick up a close win at Duke, 21-14. With the Irish trailing, 14-13, in the final two and a half minutes of regulation, quarterback Sam Hartman led a 95-yard touchdown drive capped by an Audric Estime 30-yard rushing touchdown. It put Notre Dame ahead with 30 seconds left, and they recovered a fumble two plays into Duke's ensuing drive to ice the game.

Notre Dame: Estime and Hartman help No. 11 Fighting Irish push past No. 17 Duke for 21-14 road win

How to watch Notre Dame vs. Louisville: TV channel and streaming

Game start: 7:30 p.m. ET

Location: L&N Federal Credit Union Stadium, Louisville, Kent.

Cable TV: ABC

Streaming: ESPN app

Injury news

Injury updates to come.

NCAAF odds Week 6: Notre Dame vs. Louisville lines, betting trends

Notre Dame are favorites to defeat Louisville, according to the BetMGM college football odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

Betting odds, as of Monday morning:

  • Spread: Notre Dame (-6.5)

  • Moneyline: TBD

  • Over/under: 51.5

Notre Dame quarterback Sam Hartman (10) escapes pressure from Ohio State defensive end Jack Sawyer (33) in the first quarter.
Notre Dame quarterback Sam Hartman (10) escapes pressure from Ohio State defensive end Jack Sawyer (33) in the first quarter.

Week 5 CFB Overreactions: Georgia shouldn't be No. 1, ACC should dump Notre Dame.

Louisville football remaining schedule and results

All times eastern.

  • Week 1: Louisville 39 - 34 Georgia Tech FINAL

  • Week 2: Louisville 56- 0 Murray State FINAL

  • Week 3: Louisville 21 - 14 Indiana FINAL

  • Week 4: Louisville 56 - 28 Boston College FINAL

  • Week 5: Louisville 13 - 10 NC State FINAL

  • Week 6: Louisville vs. Notre Dame, 7:30 p.m., ABC

  • Week 7: Louisville @ Pitt, TBA, TBA

  • Week 8: BYE

  • Week 9: Louisville vs. Duke, TBA, TBA

  • Week 10: Louisville vs. Virginia Tech, TBA, TBA

  • Week 11: Louisville vs. Virginia, 7:30 p.m., ESPN

  • Week 12: Louisville @ Miami (FL), TBA, TBA

  • Week 13: Louisville vs. Kentucky, TBA, TBA

College GameDay: Desmond Howard criticizes 'thin-skinned' OSU coach Ryan Day for comments on Lou Holtz

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This article originally appeared on USA TODAY: Louisville take on Notre Dame: Schedule, TV, streaming, latest odds