Kyler Murray's Arizona Cardinals look to keep the momentum going after their Week 2 comeback win over the Las Vegas Raiders when they play host to Matthew Stafford and the Los Angeles Rams.
First place in the NFC West could be on the line when Stafford, Cooper Kupp and the Rams offense comes to town. But will the Los Angeles attack be enough to offset whatever production comes from Murray, James Conner and Marquise Brown? The game is set to kick off Sunday at 4 p.m. ET from State Farm Stadium.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Rams vs. Cardi Week 3 game:
Rams at Cardinals odds, moneyline and over/under
Spread: Rams (-3.5)
Moneyline: Rams (-180); Cardinals (+155)
NFL Week 3 odds, predictions and picks
Steelers vs. Browns | Saints vs. Panthers | Texans vs. Bears | Chiefs vs. Colts | Bills vs. Dolphins | Lions vs. Vikings | Ravens vs. Patriots | Bengals vs. Jets | Raiders vs. Titans | Eagles vs. Commanders | Jaguars vs. Chargers | Rams vs. Cardinals | Falcons vs. Seahawks | Packers vs. Buccaneers | 49ers vs. Broncos | Cowboys vs. Giants
Lorenzo Reyes: Rams 27, Cardinals 21
L.A. has dominated this series, but both of these teams have been unreliable plays against the spread over their last five or six games so I think there are far better plays out there. Still, I think the Rams are slowly shaking off their early-season rust and should eventually hit their stride.
Safid Deen: Rams 28, Cardinals 24
Kyler Murray and the Cardinals were able to mount a 20-point comeback in Las Vegas last week, but their luck will not continue against the defending Super Bowl champions. Matt Stafford, Cooper Kupp and the vaunted Rams defense will affect Murray early and often as they did in the playoffs last season. While Murray will look and play better than the last time he faced the Rams, he won’t be able to avenge last season’s disastrous loss.
Lance Pugmire: Rams 27, Cardinals 17
The Super Bowl champions know better than to let Kyler Murray run unfettered as he did in the fourth quarter against the Raiders.
Jarrett Bell: Rams 31, Cardinals 27
Nate Davis: Rams 30, Cardinals 23
Tyler Dragon: Rams 30, Cardinals 21
RANKING PLAYOFF VIABILITY: Which NFL teams can survive 0-2 start to 2022 season?
NFL NEWS, DELIVERED: Breaking news, in-depth analysis delivered to your inbox. Sign up here!
SEASON PREDICTIONS: Super Bowl 57, playoffs, MVP and other awards
NFL salaries: These are the highest-paid NFL players
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.
This article originally appeared on USA TODAY: Los Angeles Rams at Arizona Cardinals predictions, picks for NFL Week 3