Los Angeles Rams at Arizona Cardinals: Predictions, picks and odds for NFL Week 12 game
Kyler Murray and the Arizona Cardinals (2-9) host the Los Angeles Rams (4-6) in an NFC West matchup at State Farm Stadium.
Murray is 1-6 against the Rams in the regular season since being drafted by the Cardinals as the No. 1 pick in the 2019 draft. Los Angeles also beat him in a wild card playoff game after the 2021 season. The Heisman Trophy winner was out with a torn ACL during his team's win against the Rams last season.
Since his return from injury, Murray beat the Atlanta Falcons with a 19-of-32 performance with 249 yards and an interception. He then lost to the Houston Texans, going 20-of-30 for 214 yards, a passing touchdown and a pick. He had a rushing touchdown in each matchup.
The Rams snapped their three-game losing streak with a come-from-behind win over another division foe, the Seattle Seahawks. Matthew Stafford continues to recover from a thumb injury and Cooper Kupp only had one catch for 11 yards.
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Cardinals vs. Rams odds, moneyline, over/under
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Spread: Rams (-1.5)
Moneyline: Rams (-120); Cardinals (+100)
Over/under: 44.5
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NFL Week 12 odds, predictions and picks
Lions vs. Packers | Cowboys vs. Commanders | Seahawks vs. 49ers | Jets vs. Dolphins | Falcons vs. Saints | Bengals vs. Steelers | Texans vs. Jaguars | Colts vs. Buccaneers | Giants vs. Patriots | Titans vs. Panthers | Cardinals vs. Rams | Broncos vs. Browns | Raiders vs. Chiefs | Eagles vs. Bills | Chargers vs. Ravens | Vikings vs. Bears
Lorenzo Reyes: Rams 21, Cardinals 18
Los Angeles has been a poor play against the spread, covering just one of its last six games. Still, that game the Rams did cover came Week 6 against the Cardinals. Kyler Murray is now healthy and Arizona is playing better. Sean McVay’s staff has come up with ways to scheme up an advantage for a roster that has some obvious holes.
Tyler Dragon: Rams 24, Cardinals 21
The Rams are 3-1 in the NFC West. Their only loss in the division came against the 49ers (of course). Arizona hasn’t won a divisional game this season. Kyler Murray’s return has made the Cardinals competitive, but Arizona’s defense gives up nearly 26 points per game. The Cardinals secondary will have their hands full against Puka Nacua, and especially Cooper Kupp (ankle), if he plays.
Safid Deen: Rams 20, Cardinals 16
Matt Stafford might be without Cooper Kupp, but the Rams still have enough firepower with Stafford as their flamethrower. Kyler Murray and the Cardinals haven’t had enough time to gel offensively and it won’t get any easier with Aaron Donald bearing down.
Victoria Hernandez: Cardinals 20, Rams 17
Kyler Murray will be hungry to get another win after losing to the Texans in his second game back last week. Matthew Stafford displayed some great heroics last week, but might be without Cooper Kupp in this matchup and said his thumb still isn't one hundred percent.
Jordan Mendoza: Rams 23, Cardinals 21
Los Angeles looked dead in the water against Seattle before it pulled off a comeback victory. With a favorable two weeks, Los Angeles could pull something together against an Arizona team still figuring it out with Kyler Murray back. This game also has the potential to be a high scoring affair.
You can view the full list of USA TODAY's NFL expert predictions here.
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This article originally appeared on USA TODAY: Los Angeles Rams at Arizona Cardinals: Game predictions, picks, odds
