Arsene Wenger and the Gunners are searching for their fifth victory of the Premier League season as they face the Hornets at Vicarage Road.
The Eagles search for their first goal and first point this Premier League season as they welcome the defending champions to Selhurst Park.
Jose Mourinho and the Reds face their toughest road test of the season at Anfield.
The two Blues are among the top three teams so far this Premier League season and square off in a key showdown at Stamford Bridge.
Manchester United continued its impressive start to the season, while Crystal Palace remained winless and scoreless this Premier League season.
Jose Mourinho and Manchester United look to continue their impressive start vs. Crystal Palace, which is scoreless and winless in six Premier League matches this season.