The 49ers have won three games in a row and four of their last five. They have scored 30 or more points while averaging 170 rushing yards across the four victories. Their one hiccup in the last five was a 31-17 loss to the Cardinals where they only mustered 39 rushing yards.
Seattle signed Adrian Peterson to its practice squad on Wednesday.
The San Francisco 49ers announced Saturday that rookie running back Trey Sermon has been placed on injured reserve with an ankle ailment. Sermon will now miss at least the next three games and won't be eligible to return until a Dec. 23 matchup against the Tennessee Titans. The 22-year-old suffered the ankle injury in the 49ers' Week 12 win over the Minnesota Vikings.