Brighton host Aston Villa on Sunday with the Seagulls aiming to get out of their slump, while Villa are closing in on Champions League qualification.
Relegated Sheffield United host Nottingham Forest at Bramall Lane on Saturday with Forest scrapping to avoid joining the Blades in the second-tier next season.
Arsenal host Bournemouth at Emirates Stadium on Saturday as the Gunners aim to keep their title hopes on track at a pivotal stage of the season.
The Crew have advanced to a club first Champions Cup final following a 3-1 victory in the second leg of the semifinals.