| Player | Interceptions |
|---|---|
| Paul Krause | 81 |
| Emlen Tunnell | 79 |
| Rod Woodson | 71 |
| Night Train Lane | 68 |
| Ken Riley | 65 |
| Charles Woodson | 65 |
| Ed Reed | 64 |
| Ronnie Lott | 63 |
| Darren Sharper | 63 |
| Dave Brown | 62 |
| Dick LeBeau | 62 |
| Emmitt Thomas | 58 |
| Bobby Boyd | 57 |
| Mel Blount | 57 |
| Johnny Robinson | 57 |
| Eugene Robinson | 57 |
| Everson Walls | 57 |
| Pat Fischer | 56 |
| Lem Barney | 56 |
| Aeneas Williams | 55 |
| Darrell Green | 54 |
| Eric Allen | 54 |
| Willie Brown | 54 |
| Ty Law | 53 |
| Deion Sanders | 53 |
| Jack Butler | 52 |
| Larry Wilson | 52 |
| Jimmy Patton | 52 |
| Champ Bailey | 52 |
| Bobby Dillon | 52 |
| Mel Renfro | 52 |
| Asante Samuel | 51 |
| Bobby Bryant | 51 |
| Donnie Shell | 51 |
| Terrell Buckley | 50 |
| Deron Cherry | 50 |
| John Harris | 50 |
| Yale Lary | 50 |
| Don Burroughs | 50 |
| Ken Houston | 49 |
| Jake Scott | 49 |
| Richie Petitbon | 48 |
| Dave Grayson | 48 |
| Willie Wood | 48 |
| Dave Waymer | 48 |
| Herb Adderley | 48 |
| Ronde Barber | 47 |
| Ray Buchanan | 47 |
| Troy Vincent | 47 |
| Jim Johnson | 47 |
| Lemar Parrish | 47 |
| Mike Haynes | 46 |
| Goose Gonsoulin | 46 |
| Jack Christiansen | 46 |
| Dave Whitsell | 46 |
| Ed Meador | 46 |
| James Hasty | 45 |
| Jim Norton | 45 |
| Thom Darden | 45 |
| Erich Barnes | 45 |
| Steve Foley | 44 |
| Dre' Bly | 43 |
| DeAngelo Hall | 43 |
| Cris Dishman | 43 |
| Kermit Alexander | 43 |
| Sammy Knight | 42 |
| Albert Lewis | 42 |
| Ashley Ambrose | 42 |
| Terence Newman | 42 |
| Gill Byrd | 42 |
| Bobby Hunt | 42 |
| Don Doll | 41 |
| Aaron Glenn | 41 |
| Johnny Sample | 41 |
| Charlie Waters | 41 |
| Carl Lockhart | 41 |
| W.K. Hicks | 40 |
| Ed Sharockman | 40 |
| Roger Wehrli | 40 |
| Billy Thompson | 40 |
| Warren Lahr | 40 |
| Tim McDonald | 40 |
| Butch Byrd | 40 |
| Tom Keane | 40 |
| Gary Barbaro | 39 |
| Tory James | 39 |
| Rolland Lawrence | 39 |
| Lester Hayes | 39 |
| Glen Edwards | 39 |
| Clarence Scott | 39 |
| Lindon Crow | 38 |
| Eric Davis | 38 |
| LeRoy Butler | 38 |
| Gary Fencik | 38 |
| Ray Brown | 38 |
| Sam Madison | 38 |
Reggie Nelson* | 38 |
| Donnie Abraham | 38 |
| Rick Volk | 38 |
| Mike Harden | 38 |