The Seattle Seahawks have had five PED-related suspensions since 2011, tops in the NFL, and Harbaugh has taken notice.
"If you cheat to win, then you've already lost, according to Bo Schembechler," said Harbaugh, quoting his college coach.
For Harbaugh, it's a black-and-white issue.
"It has no place in an athlete's body. Play by the rules," he said. "You want to be above reproach, especially when you're good, because you don't want people to come back and say, 'They're winning because they're cheating.'"
San Francisco isn't without a link to PEDs though, as former linebacker Larry Grant, currently a free agent, faces a four-game suspension before he would be eligible to play.
"I've heard this thrown out or that, but that's usually the agent or the players themselves saying it's, for example, Adderall," Harbaugh said. "But the NFL doesn't release what it actually is, so you have no idea.
"You're taking somebody at their word that I don't know if you can take them at their word, understanding the circumstances."
Seahawks cornerback Richard Sherman, who played for Harbaugh at Stanford, tested positive last season but had his suspension overturned after successfully arguing the testing process was flawed.
The 49ers and Yahoo! jointly announced Monday that Yahoo! will be the exclusive online sports content, social networking, and photo and video sharing provider for the team and Levi's Stadium.
The 10-year deal begins in 2014 when the 49ers move into Levi's Stadium in Santa Clara. Yahoo! will provide in-stadium entertainment with its photo and video sharing site, Flickr, and Yahoo! Sports Fantasy Football.
"The 49ers are thrilled to partner with Yahoo!, a locally-based, global brand that shares our vision for Levi's Stadium," 49ers CEO Jed York said in a statement. "Yahoo! is a tremendous example of Silicon Valley innovation at work. Their experience in servicing the fan and wealth of resources will serve integral roles as we strive to present an unparalleled experience to visitors of Levi's Stadium."
Yahoo! will have entitlement and branding rights to the stadium's Fantasy Football lounge and two adjacent viewing platforms in the stadium's suite tower. It will also be integrated into the in-stadium broadcast and digital media for fans.
Fans will be able to use Flickr at various areas in the stadium to upload photos to the 49ers Flickr photo gallery with the chance to be shown on one of the big screens during the game.
"The San Francisco 49ers aren't just a Sunday habit, they're a daily passion for fans throughout Northern California and across the world," Kathy Savitt, Yahoo! chief marketing officer said in a statement. "We're thrilled that two iconic brands have come together around a common goal of providing the most inspiring and entertaining fan experience in all of sports. We couldn't be more excited to be a part of what will be an incredible environment at Levi's Stadium."
The 49ers were 11-4-1 last season, but they weren't able to beat the division-rival St. Louis Rams. Both games went into overtime, with one ending in a tie, and the Rams winning the other.
Now, 49ers safety Craig Dahl, who was signed away from the Rams in the offseason, said the Rams had success against San Francisco last season because the 49ers were tipping offensive plays.
"We had a few tips off of film that we were able to differentiate between run and pass early," Dahl said. "So that kind of gave us an added benefit on defense. It was a few different things. Some different personnel and alignment stuff really were the big keys, as far as our giveaways."
Naturally, Dahl told the team what he knew after signing on March 17. He said, "It's stuff that's been corrected. It's just them discussing what kind of things we prepared for when I was in St. Louis last year, as far as scouting and different things we saw game-planning against the 49ers' offense. Kind of working with the offensive coaches on that aspect, and also kind of giving them tips and tendencies on their offense.
"It's been addressed and corrected. They knew most of it before I even got here, and it's re-confirming. It's just ongoing, self-studying and self-scouting stuff. Got that cleared up, too."
It's also notable that 49ers coach Jim Harbaugh recently added former NFL head coach and defensive coordinator Eric Mangini as a senior offensive consultant. In discussing Mangini's role, Harbaugh said, "I feel like we added a really talented, knowledgeable coach. You look at how defenses are going to prepare for us, and where we can attack defenses. That's what his role will be, helping game planning and overall offensive scheme."
Meanwhile, sweetening even more rivalry between the Rams and 49ers, Rams cornerback Corland Finnegan responded to Dahl's claim on Twitter by writing, "Craig Dahl is lame and weak for that glad he with another squad we know how he play thanks for the tips we know who 2 go at."
In a later tweet, Finnegan said, "Craig Dahl we know how you play thanks for the tips we know who to attack early and often."
49ers Kaepernick impressed by Jenkins' improvement
With their top returning wide receiver, Michael Crabtree, out indefinitely with a torn Achilles tendon, it was good news June 13 for the 49ers when quarterback Colin Kaepernick said he was thrilled with the development of his remaining receivers.
He said he was impressed with the development of A. J. Jenkins, last year's first-round draft pick who was active in only three games during the 2012 season.
"Leaps and bounds ahead of where he was last year," said Kaepernick of Jenkins' improvement. But this isn't surprising to Kaepernick, who spent two months during the offseason working out with Jenkins and getting to know each other.
Offensive coordinator Greg Roman definitely noticed Jenkins' improvement.
"The last two days of last week (June 5-6), he had the two best days he's had since I've been here," Roman said. "Just made some clutch catches for us when we were moving the ball. Just made plays, did all the right things, made plays when he had the opportunity and he just needs to continue doing that."
Jenkins said that bonding with Kaepernick off the field had a major impact with how they work together on the field.
"I never really hung out with him outside of football, so I was just going down there with him, chilling with him, staying with him, getting to know who he is and who I am as a person," Jenkins said.
"I think there's a natural process that goes on, a comfort level and that's something that's growing all the time and needs to continue to grow," Roman said.
Jenkins said he set his sights on playing more this year, and that was long before Crabtree was injured.
"My mindset going into this offseason was just trying to play more, regardless of whether Crabtree was hurt or not," he said. "It's unfortunate that he got an injury, but my mindset didn't waver at all because he got hurt."
Both Kaepernick and Jenkins said they were impressed by veteran wide receiver Anquan Boldin, previously of the Baltimore Ravens.
"He shows his veteran awareness," Kaepernick said. "I learn from him just watching him run a pattern."
Cornerback Nnamdi Asomugah is still learning defensive coordinator Vic Fangio's system and his role isn't clear, but that hasn't stopped him from taking on a leadership role.
"I've always been a leader throughout my career, I would definitely say that," Asomugah said. "The guys have looked at me in that way already and I'm just stepping foot here for a couple months."
Rookie quarterback B.J. Daniels spent some time working at wide receiver and on special teams. He doesn't anticipate supplanting LaMichael James as a returner, but has been taking reps there in practice. Daniels has never played a position other than quarterback going back to his youth.
"I know one of the things I look back and think that I made a mistake on personally was probably not putting that tag on (Parys Haralson), that exemption that he could have come back and played because he was healthy and ready to go probably mid-to-late December."—Jim Harbaugh on Parys Haralson's torn triceps last season.
(not tendered offers)
G Leonard Davis (not tendered as UFA).
LB Tavares Gooden (not tendered as UFA).
LB Larry Grant (not tendered as UFA).
LB Clark Haggans (not tendered as UFA).
WR Randy Moss (not tendered as UFA).
DE Cornellius Carradine (2/40): 4 yrs, terms unknown.
TE Vance McDonald (2/55): 4 yrs, terms unknown.
LB Corey Lemonier (3/88): 4 yrs, terms unknown.
WR Quinton Patton (4/128): 4 yrs, terms unknown.
RB Marcus Lattimore (4/131): 4 yrs, terms unknown.
DT Quinton Dial (5/157): $2.34M/4 yrs, $181,000 SB.
LB Nick Moody (6/180): 4 yrs, terms unknown.
QB B.J. Daniels (7/237): $2.207M/4 yrs, $46,512SB.
T Carter Bykowski (7/246): $2.206M/4 yrs, $45,896 SB.
CB Marcus Cooper (7/252): $2/206M/4 yrs, $45,896 SB.
CB Tramaine Brock: RFA tendered at $1.323M with no compensation); 1 yr, terms unknown.
S Darcel McBath: Not tendered as RFA; 1 yr, terms unknown.
CB Nnamdi Asomugha: FA Eagles; $1.35M/1 yr.
WR Anquan Boldin (trade).
S Craig Dahl: UFA Rams; $5.25M/3 yrs, $700,000 SB.
K Phil Dawson: UFA Browns; $2.25M/1 yr, $1M SB.
DE Glenn Dorsey: UFA Chiefs; $6M/2 yrs, $2.285M SB.
QB Colt McCoy (trade Browns).
WR Marlon Moore: Not tendered as RFA by Dolphins; 1 yr, terms unknown.
WR Kassim Osgood: Not tendered as UFA by Lions; 1 yr, terms unknown.
LB Dan Skuta: UFA Bengals; $3M/2 yrs, $300,000 SB.
OL Adam Snyder: UFA Arizona Cardinals; 2 yrs, terms unknown.
S Ray Ventrone: Not tendered as UFA by Browns; 2 yrs, terms unknown.
K David Akers (released/failed physical).
WR/KR Ted Ginn: UFA Panthers; 1 yr, terms unknown.
S Dashon Goldson: UFA Buccaneers; $41.25M/5 yrs, $22M guaranteed.
DT Ricky Jean Francois: UFA Colts; $22M/4 yrs, $8.5M guaranteed/$6.5M fully guaranteed.
QB Alex Smith (traded).
NT Isaac Sopoaga: UFA Eagles; $11M/3 yrs.
TE Delanie Walker: UFA Titans; $17.5M/4 yrs.