Lozano, a winger with PSV Eindhoven and the Mexican national team, will be San Diego's first Designated Player in its inaugural season.
Gregg Berhalter has some decisions to make with his XI heading into Copa America, as a deep pool of midfielders would challenge any manager.
A deep group of internationally-based United States men's national team players has turned its attention to the summer and Copa America.
Gregg Berhalter's USMNT get a high-profile Copa America tune-up when Luis Diaz and Los Cafeteros visit Commanders Field on Saturday.