| | T | Cut (Signed) |
| | S | Signed (Signed) To |
| | WR | Cut (Signed) |
| | RB | Signed (Signed) To |
| | WR | Signed (Signed) From |
| | C | Signed (Signed) |
| | DT | Signed/unrest FA (Signed) To |
| | DE | Cut (Signed) |
| | DT | Signed (Signed) |
| | DE | Signed (Signed) To |
| | DT | Cut (Signed) |
| | WR | Cut (Signed) |
| | WR | Signed (Signed) From |
| | WR | Signed/unrest FA (Signed) From |
| | S | Placed on PUPL (undisclosed) |
| | DE | Placed on PUPL (undisclosed) |
| | LB | Placed on PUPL (undisclosed) |
| | WR | Placed on PUPL (undisclosed) |
| | DE | Cut (Signed) |
| | DT | Acquired from waiver (Signed) From |
| | LB | Signed (Signed) To |
| | S | Retired (Signed) |
| | DE | Signed/unrest FA (Signed) From |
| | DE | Cut (Signed) |
| | T | Signed/unrest FA (Signed) From |
| | DE | Signed/unrest FA (Signed) From |
| | DT | Cut (Signed) |
| | LB | Cut (Signed) |
| | DT | Signed (Signed) |
| | QB | Signed (Signed) To |
| | C | Cut (Signed) |
| | RB | Signed/unrest FA (Signed) From |
| | QB | Signed (Two-year contract (through 2023)) From |
| | QB | Cut (Signed) |
| | T | Signed/draft choice (Four-year contract (through 2025)) |
| | TE | Signed/draft choice (Four-year contract (through 2025)) |
| | T | Signed (Signed) To |
| | RB | Cut (Signed) |
| | RB | Signed/unrest FA (One-year contract (through 2022)) From |
| | WR | Signed/draft choice (Four-year contract (through 2025)) |
| | C | Signed (Signed) |
| | DT | Signed (Signed) |
| | T | Signed (Signed) |
| | DE | Signed (Signed) |
| | WR | Signed (Signed) |
| | DE | Signed (Signed) |
| | LB | Signed (Signed) |
| | S | Signed/draft choice (Four-year contract (through 2025)) |
| | G | Signed (Signed) |
| | CB | Signed (Signed) |
| | WR | Signed (Signed) |
| | DT | Signed/draft choice (Four-year contract (through 2025)) |
| | S | Signed/draft choice (Four-year contract (through 2025)) |
| | QB | Signed (Signed) |
| | LB | Signed (Signed) |
| | WR | Signed (Signed) |
| | WR | Signed (Signed) |
| | LB | Signed (Signed) |
| | TE | Signed/draft choice (Four-year contract (through 2025)) |
| | RB | Signed (Signed) |
| | RB | Signed (Signed) |
| | DT | Signed/draft choice (Four-year contract (through 2025)) |
| | RB | Signed (Signed) |
| | LB | Signed (Signed) |
| | C | Signed (Signed) |
| | S | Signed (Signed) |
| | TE | Acquired from waiver (Signed) To |
| | LB | Cut (Signed) |
| | T | Cut (Signed) |
| | T | Signed/unrest FA (Signed) From |
| | TE | Cut (Signed) |
| | TE | Cut (Signed) |
| | CB | Signed (International Player Pathway Program) |
| | T | Signed/unrest FA (One-year contract (through 2022)) To |
| | DE | Signed/unrest FA (One-year contract (through 2022)) To |
| | WR | Re-signed/rest FA (One-year contract (through 2022)) |
| | CB | Signed/unrest FA (Two-year contract (through 2023)) From |
| | T | Signed (One-year contract (through 2022)) From |
| | S | Signed/unrest FA (Signed) From |
| | DE | Signed/unrest FA (One-year contract (through 2022)) To |
| | LB | Signed/unrest FA (One-year contract (through 2022)) From |
| | RB | Signed/unrest FA (One-year contract (through 2022)) To |
| | LB | Signed/unrest FA (One-year contract (through 2022)) To |
| | DT | Signed/unrest FA (One-year contract (through 2022)) To |
| | G | Signed/unrest FA (Two-year contract (through 2023)) To |
| | S | Signed/unrest FA (One-year contract (through 2022)) From |
| | WR | Signed/unrest FA (One-year contract (through 2022)) To |
| | S | Signed/unrest FA (Three-year contract (through 2024)) To |
| | QB | Traded (for 2022 third-round draft pick) From |
| | CB | Signed/unrest FA (One-year contract (through 2022)) From |
| | DE | Signed/unrest FA (Two-year contract (through 2023)) To |
| | G | Signed/unrest FA (Three-year contract (through 2024)) To |
| | DE | Declared Free Agent (Signed) |
| | CB | Traded (for DE Yannick Ngakoue) To |
| | T | Declared Free Agent (Signed) |
| | T | Declared Free Agent (Signed) |
| | QB | Traded (for 2022 2nd and 2023 3rd-round picks) To |
| | DE | Traded (for CB Rock Ya-Sin) From |
| | S | Declared Free Agent (Signed) |
| | DE | Re-signed (One-year contract (through 2022)) |
| | LB | Re-signed (Three-year contract (through 2024)) |
| | DT | Declared Free Agent (Signed) |
| | DT | Declared Free Agent (Signed) |
| | T | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | DE | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | K | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | G | Declared Free Agent (Signed) |
| | S | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | S | Declared Free Agent (Signed) |
| | G | Declared Free Agent (Signed) |
| | DE | Declared Free Agent (Signed) |
| | WR | Restricted Free Agent (Signed) |
| | RB | Declared Free Agent (Signed) |
| | T | Re-signed (One-year extension (through 2022)) |
| | DT | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | TE | Re-signed (Three-year contract (through 2024)) |
| | CB | Signed (Signed) From |
| | TE | Retired (Signed) |
| | TE | Signed (Signed) |
| | T | Signed (Signed) |
| | CB | Signed (Signed) |
| | K | Signed (Signed) From |
| | DT | Signed (Signed) From |
| | TE | Signed (Signed) To |
| | S | Pract. squad del (Signed) |
| | CB | Pract. squad del (Signed) |
| | QB | Pract. squad del (Signed) |