| | DT | Signed (The Buffalo Bills signed DT Gable Steveson.) |
| | P | Released (The Buffalo Bills released P Matt Haack.) |
| | WR | Released (The Buffalo Bills released WR Quintez Cephus.) |
| | DB | Signed (The Buffalo Bills signed S Dee Delaney.) |
| | WR | Signed (The Buffalo Bills signed WR Marquez Valdes-Scantling.) |
| | LB | Signed (The Buffalo Bills signed LB Joe Andreessen.) |
| | DE | Signed (The Buffalo Bills signed DT Rondell Bothroyd.) |
| | DE | Signed (The Buffalo Bills signed DE David Ugwoegbu.) |
| | OL | Signed (The Buffalo Bills signed OL Mike Edwards.) |
| | CB | Signed (The Buffalo Bills signed CB Te'Cory Couch.) |
| | OT | Signed (The Buffalo Bills signed OT Travis Clayton.) |
| | CB | Signed (The Buffalo Bills signed CB Travis Blackshear.) |
| | TE | Signed (The Buffalo Bills signed TE Mason Fairchild.) |
| | LB | Signed (The Buffalo Bills signed LB Kolbi Fuqua.) |
| | OL | Signed (The Buffalo Bills signed OL Michael Furtney.) |
| | DE | Signed (The Buffalo Bills signed DE Paul Nelson.) |
| | DL | Signed (The Buffalo Bills signed DL Devin Phillips.) |
| | DE | Signed (The Buffalo Bills signed OLB Dawuane Smoot.) |
| | WR | Signed (The Buffalo Bills signed WR Chase Claypool.) |
| | MLB | Signed (The Buffalo Bills signed LB Deion Jones.) From |
| | CB | Signed (The Buffalo Bills signed CB Keni-H Lovely.) |
| | OG | Signed (The Buffalo Bills signed OL Gunner Britton.) |
| | QB | Signed (The Buffalo Bills signed QB Gunnar Watson.) |
| | DB | Signed (The Buffalo Bills signed S Alfahiym Walcott.) |
| | WR | Signed (The Buffalo Bills signed WR Xavier Johnson Jr.) |
| | RB | Signed (The Buffalo Bills signed RB Frank Gore Jr.) |
| | WR | Signed (The Buffalo Bills signed WR Lawrence Keys III.) |
| | OG | Signed (The Buffalo Bills signed OG Keaton Bills.) |
| | CB | Signed (The Buffalo Bills signed CB Sheridan Jones.) |
| | WR | Signed (The Buffalo Bills signed WR Quintez Cephus.) |
| | DT | Signed (The Buffalo Bills signed IDL Branson Deen.) |
| | P | Signed (The Buffalo Bills signed P Jack Browning.) |
| | DT | Signed (The New England Giants signed DT Jordan Phillips.) To |
| | T | Signed (The Buffalo Bills signed OT La'el Collins.) |
| | WR | Traded (The Buffalo Bills traded WR Stefon Diggs to the Houston Texans.) To |
| | DT | Signed (The Buffalo Bills signed DT DeShawn Williams.) From |
| | QB | Declared Free Agent (QB Kyle Allen elected free agency.) |
| | RB | Retired (Buffalo Bills RB Damien Harris retired from the NFL.) |
| | DT | Signed (The Buffalo Bills signed DL Austin Johnson.) |
| | OL | Signed (The Buffalo Bills signed OL Will Clapp.) |
| | S | Signed (The Buffalo Bills signed S Mike Edwards.) From |
| | DE | Signed (The Buffalo Bills signed DE Casey Toohill.) |
| | LB | Declared Free Agent (LB Tyrel Dodson elected free agency.) |
| | WR | Declared Free Agent (WR Trent Sherfield elected free agency.) |
| | DT | Declared Free Agent (DT Tim Settle elected free agency.) |
| | WR | Signed (The Buffalo Bills signed WR Curtis Samuel.) |
| | DT | Declared Free Agent (Buffalo Bills DT Poona Ford declared free agency.) |
| | CB | Declared Free Agent (Buffalo Bills CB Dane Jackson declared free agency.) |
| | LB | Signed (The Buffalo Bills signed LB Nicholas Morrow.) |
| | WR | Signed (The Buffalo Bills signed WR Mack Hollins.) |
| | DL | Declared Free Agent (DE Leonard Floyd elected free agency.) |
| | WR | Declared Free Agent (WR Gabe Davis elected free agency.) |
| | DB | Released (The Buffalo Bills released CB Tre'Davious White.) |
| | S | Released (The Buffalo Bills released SAF Jordan Poyer.) |
| | QB | Signed (The Buffalo Bills signed QB Mitch Trubisky.) |
| | P | Re-signed (The Buffalo Bills re-signed P Matt Haack.) |
| | RB | Released (The Buffalo Bills released RB Nyheim Hines.) |
| | CB | Released (The Buffalo Bills released CB Siran Neal.) |
| | WR | Released (The Buffalo Bills released WR Deonte Harty.) |
| | C | Released (The Buffalo Bills released C Mitch Morse.) |
| | OL | Traded (The Buffalo Bills traded OL Ryan Bates to the Chicago Bears.) To |
| | DL | Contract Expired (DL Andrew Brown's contract expired with the Buffalo Bills.) |
| | CB | Contract Expired (CB Josh Norman's contract expired with the Buffalo Bills.) |
| | OL | Contract Expired (DL Greg Mancz's contract expired with the Buffalo Bills.) |
| | G | Contract Expired (G Germain Ifedi's contract expired with the Buffalo Bills.) |
| | LB | Contract Expired (LB A.J. Klein's contract expired with the Buffalo Bills.) |
| | DT | Signed (The Buffalo Bills signed DT Eli Ankou to a reserve/future contract.) |
| | QB | Signed (The Buffalo Bills signed QB Shane Buechele to a reserve/future contract.) |
| | RB | Signed (The Buffalo Bills signed RB Darrynton Evans to a reserve/future contract.) From |
| | OL | Signed (The Buffalo Bills signed OL Kevin Jarvis to a reserve/future contract.) |
| | DE | Signed (The Buffalo Bills signed DE Kameron Cline to a reserve/future contract.) |
| | T | Signed (The Buffalo Bills signed T Richard Gouraige to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Bryan Thompson to a reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Kyron Brown to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Andy Isabella to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Tyrell Shavers to a reserve/future contract.) |
| | DB | Signed (The Buffalo Bills signed DB Kendall Williamson to a reserve/future contract from the Chicago Bears practice squad.) From |
| | TE | Signed (The Buffalo Bills signed TE Tre' McKitty to reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Ja'Marcus Ingram to a reserve/future contract.) |
| | LB | Activated (The Buffalo Bills elevated LB A.J. Klein from the practice squad.) |
| | P | Released (The Buffalo Bills released P Matt Haack.) |
| | DT | Pract. squad add (The Buffalo Bills signed DT Eli Ankou to the practice squad.) |
| | WR | Signed (The Buffalo Bills signed WR KJ Hamler to a reserve/futures deal.) From |
| | WR | Activated (The Buffalo Bills elevated WR Andy Isabella from the practice squad.) |
| | P | Pract. squad add (The Buffalo Bills signed P Matt Haack to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR Andy Isabella to the practice squad.) |
| | RB | Released (The Buffalo Bill have released RB Leonard Fournette.) |
| | LB | Pract. squad add (The Buffalo Bills assigned LB A.J. Klein to the practice squad.) |
| | LB | Activated (The Buffalo Bills signed LB A.J. Klein to the active roster.) |
| | WR | Activated (The Buffalo Bills signed WR Andy Isabella to the active roster.) |
| | DT | Released (The Buffalo Bills released DL Eli Ankou.) |
| | LB | Pract. squad add (The Buffalo Bills signed LB A.J. Klein to the practice squad.) |
| | RB | Pract. squad add (The Buffalo Bills assigned RB Leonard Fournette to the practice squad.) |
| | RB | Activated (The Buffalo Bills elevated RB Leonard Fournette from the practice squad.) |
| | G | Pract. squad add (The Buffalo Bills signed G Germain Ifedi to the practice squad.) |
| | CB | Released (The Buffalo Bills released CB Tre Norwood.) |
| | DT | Activated (The Buffalo Bills activated DT DaQuan Jones from the IRD.) |
| | CB | Released (The Buffalo Bills released DB Herb Miller.) |
| | DE | Pract. squad add (The Buffalo Bills assigned DL Kameron Cline to the practice squad.) |
| | G | Waived (The Buffalo Bills waived G Germain Ifedi.) |
| | CB | Activated (The Buffalo Bills activated DB Kaiir Elam.) |
| | RB | Activated (The Buffalo Bills elevated RB Leonard Fournette to the active roster from the practice squad.) |
| | DT | Placed on Injured Reserve (The Buffalo Bills placed DL Jordan Phillips on IR.) |
| | DT | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed DL DaQuan Jones on IRD.) |
| | WR | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed WR Justin Shorter on IRD.) |
| | LB | Released (The Buffalo Bills released LB A.J. Klein.) |
| | TE | Activated (The Buffalo Bills activated TE Dawson Knox from injured reserve.) |
| | TE | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed TE Dawson Knox on the IRD.) |
| | CB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed CB Kaiir Elam on the IRD.) |
| | WR | Activated (The Buffalo Bills elevated WR Andy Isabella to the active roster.) |
| | CB | Activated (The Buffalo Bills elevated CB Ja'Marcus Ingram to the active roster.) |
| | CB | Activated (The Buffalo Bills elevated CB Josh Norman to the active roster.) |
| | DE | Placed on Injured Reserve (The Buffalo Bills placed DE Kameron Cline on practice squad injured reserve.) |
| | CB | Pract. squad add (The Buffalo Bills signed SAF Tre Norwood to the practice squad.) |
| | TE | Pract. squad add (The Buffalo Bills signed TE Tre' McKitty to the practice squad.) |
| | TE | Released (The Buffalo Bills released TE Joel Wilson.) |
| | CB | Activated (The Buffalo Bills elevated CB Josh Norman to the active roster.) |
| | CB | Placed on Injured Reserve (The Buffalo Bills placed DB Kaiir Elam on IR.) |
| | DT | Signed (The Buffalo Bills signed DL Linval Joseph.) |