| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RHP Chris Roycroft from the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Ryan Loutos to the minors.) |
| | 2B | Recalled From Minors Rehab (The St. Louis Cardinals recalled INF José Fermín from the minors.) |
| | RF | Placed on 10-Day IL (The St. Louis Cardinals placed OF Lars Nootbaar on the 10-day injured list.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RHP Andre Pallante from the minors.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed RHP Nick Robertson on the 15-day injured list with elbow inflammation.) |
| | 1B | Sent to Minors (The St. Louis Cardinals sent INF Alfonso Rivas outright to the minors. ) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RHP Chris Roycroft from the minors. He will serve as the Cardinals' 27th player in its doubleheader against the O's.) |
| | P | Sent to Minors (The St. Louis Cardinals returned 27th man RHP Chris Roycroft to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Chris Roycroft to the minors.) |
| | 1B | Designated for Assignment (The St. Louis Cardinals designated INF Alfonso Rivas for assignment.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals selected the contract of RHP Ryan Loutos from the minors.) |
| | P | Released (The St. Louis Cardinals released RHP Josh James.
) |
| | DH | Activated (The St. Louis Cardinals activated DH Matt Carpenter from the 10-day injured list.) |
| | 2B | Sent to Minors (The St. Louis Cardinals optioned INF José Fermín to the minors.) |
| | P | Placed on 60-Day IL (The St. Louis Cardinals transferred RP Riley O'Brien to the 60-day injury list.) |
| | P | Claimed on Unconditional Release Waivers (The St. Louis Cardinals claimed RP Kolton Ingram off waivers from the Texas Rangers.) |
| | C | Recalled From Minors Rehab (The St. Louis Cardinals recalled C Pedro Pagés from the minors.) |
| | C | Placed on 10-Day IL (The St. Louis Cardinals placed C Willson Contreras on the 10-day injured list.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed RHP Giovanny Gallegos on the 15-day injured list with a shoulder injury.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals selected the contract of RHP Chris Roycroft from the minors.) |
| | SS | Placed on 60-Day IL (The St. Louis Cardinals transferred INF Tommy Edman to the 60-day injured list.) |
| | C | Sent to Minors (The St. Louis Cardinals optioned C Pedro Pagés to the minors.) |
| | RF | Activated (The St. Louis Cardinals activated OF Dylan Carlson from the 10-day injured list.) |
| | P | Released (The St. Louis Cardinals released RHP Connor Lunn.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RHP Kyle Leahy from the minors.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed LHP Steven Matz on the 15-day injured list.) |
| | P | Sent to Minors (The St. Louis Cardinals sent RHP Kyle Leahy to the minors.) |
| | P | Placed on 60-Day IL (The St. Louis Cardinals placed RP Drew Rom on the 60-day injured list.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RP Kyle Leahy from the minors.) |
| | 2B | Recalled From Minors Rehab (The St. Louis Cardinals recalled INF José Fermín from the minors.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled LHP John King from the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned LHP Zack Thompson to the minors.) |
| | RF | Sent to Minors (The St. Louis Cardinals optioned OF Jordan Walker to the minors.) |
| | CF | Sent to Minors (The St. Louis Cardinals optioned OF Victor Scott to the minors.) |
| | C | Recalled From Minors Rehab (The St. Louis Cardinals recalled INF Pedro Pagés from the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Andre Pallante to the minors.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RHP Nick Robertson from the minors.) |
| | RF | Activated (The St. Louis Cardinals activated OF Lars Nootbaar from the 10-day injured list.) |
| | C | Sent to Minors (The St. Louis Cardinals optioned C Pedro Pagés to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned LHP John King to the minors.) |
| | P | Activated (The St. Louis Cardinals activated RHP Sonny Gray from the 15-day injured list.) |
| | C | Recalled From Minors Rehab (The St. Louis Cardinals recalled C Pedro Pagés from the minors.) |
| | DH | Placed on 10-Day IL (The St. Louis Cardinals placed DH Matt Carpenter on the 10-day injured list with an oblique strain.) |
| | RF | Sent to Minors (The St. Louis Cardinals sent LF Lars Nootbar to the minors on a rehab assignment.) |
| | 1B | Sent to Minors (The St. Louis Cardinals sent INF Jared Young outright to the minors.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed RP Riley O'Brien on the 15-Day Injury List with a flexor strain in his right forearm.) |
| | P | Recalled From Minors Rehab (The St. Louis Cardinals recalled RP John King from the minors.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed LHP Drew Rom on the 15-day injured list.) |
| | C | Sent to Minors (The St. Louis Cardinals optioned C Pedro Pagés to the minors.) |
| | 2B | Sent to Minors (The St. Louis Cardinals optioned INF José Fermín to the minors.) |
| | SS | Placed on 10-Day IL (The St. Louis Cardinals placed INF Tommy Edman on the 10-day injured list.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed RHP Keynan Middleton on the 15-day injured list.) |
| | RF | Placed on 10-Day IL (The St. Louis Cardinals placed OF Lars Nootbaar on the 10-day injured list.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned LHP John King to the minors.) |
| | P | Placed on 15-Day IL (The St. Louis Cardinals placed RHP Sonny Gray on the 15-day injured list.) |
| | RF | Placed on 10-Day IL (The St. Louis Cardinals placed OF Dylan Carlson on the 10-day injured list.) |
| | 1B | Designated for Assignment (The St. Louis Cardinals designated INF Jared Young for assignment.) |
| | CF | Recalled From Minors Rehab (The St. Louis Cardinals selected the contract of OF Victor Scott from the minors.) |
| | SS | Sent to Minors (The St. Louis Cardinals sent INF César Prieto to the minors.) |
| | 1B | Sent to Minors (The St. Louis Cardinals optioned INF Luken Baker to the minors.) |
| | 1B | Sent to Minors (The St. Louis Cardinals optioned INF Jared Young to the minors.) |
| | CF | Sent to Minors (The St. Louis Cardinals sent OF Victor Scott to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Nick Robertson to the minors.) |
| | 1B | Sent to Minors (The St. Louis Cardinals optioned INF Alfonso Rivas to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned RHP Ryan Loutos to minor league camp.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned RHP Gordon Graceffo to minor league camp.) |
| | SS | Sent to Minors (The St. Louis Cardinals assigned INF Jeremy Rivas to minor league camp.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Sem Robberse to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned LHP Connor Thomas to minor league camp.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned RHP Michael McGreevy to minor league camp.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned RHP Tekoah Roby to minor league camp.) |
| | SS | Sent to Minors (The St. Louis Cardinals assigned INF Arquímedes Gamboa to minor league camp.) |
| | C | Sent to Minors (The St. Louis Cardinals assigned C Aaron Antonini to minor league camp.) |
| | C | Sent to Minors (The St. Louis Cardinals assigned C Jimmy Crooks to minor league camp.) |
| | P | Sent to Minors (The St. Louis Cardinals optioned RHP Adam Kloffenstein to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals assigned LHP Cooper Hjerpe to minor league camp.) |
| | LF | Sent to Minors (The St. Louis Cardinals sent OF Moisés Gómez to the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals sent LHP Packy Naughton to the minors.) |
| | 2B | Designated for Assignment (The St. Louis Cardinals designated INF Buddy Kennedy for assignment.) |
| | SS | Signed (The St. Louis Cardinals signed INF Brandon Crawford.) |
| | P | Signed (The St. Louis Cardinals signed RHP Jacob Bosiokovic to a minor league contract.) |
| | P | Traded (The St. Louis Cardinals traded RHP Guillermo Zuñiga to the Los Angeles Angels.) To |
| | LF | Non-roster Invitee (The St. Louis Cardinals invited OF Moisés Gómez to spring training.) |
| | P | Designated for Assignment (The St. Louis Cardinals designated RHP Guillermo Zuñiga for assignment.) |
| | P | Signed (The St. Louis Cardinals signed RHP Keynan Middleton.) |
| | LF | Designated for Assignment (The St. Louis Cardinals designated OF Moisés Gómez for assignment.) |
| | 1B | Claimed on Unconditional Release Waivers (The St. Louis Cardinals claimed INF Alfonso Rivas from the Los Angeles Angels.) |
| | P | Non-roster Invitee (The St. Louis Cardinals invited non-roster RHP Josh James to spring training.) |
| | P | Signed (The St. Louis Cardinals signed RHP Josh James to a minor league contract.) |
| | P | Signed (The St. Louis Cardinals signed LHP Nick Raquet to a minor league contract.) |
| | C | Signed (The St. Louis Cardinals signed C Jonathan Morales to a minor league contract.) |
| | P | Signed (The St. Louis Cardinals signed LHP Nick Raquet to a minor league contract.) |
| | C | Signed (The St. Louis Cardinals signed C Jonathan Morales to a minor league contract.) |
| | DH | Signed (The St. Louis Cardinals signed DH Matt Carpenter.) |
| | P | Declared Free Agency (RHP James Naile elected free agency.) |
| | P | Traded (The Tampa Bay Rays traded RHP Andrew Kittredge to the St. Louis Cardinals.) From |
| | RF | Traded (The St. Louis Cardinals traded INF Richie Palacios to the Tampa Bay Rays.) To |
| | C | Signed (The St. Louis Cardinals signed C Gavin Collins to a minor league contract.) |
| | P | Traded (The Boston Red Sox traded RHP Victor Santos to the St. Louis Cardinals.) From |
| | LF | Traded (The St. Louis Cardinals traded OF Tyler O'Neill to the Boston Red Sox.) To |
| | P | Traded (The Boston Red Sox traded RHP Nick Robertson to the St. Louis Cardinals.) From |
| | P | Drafted Via Rule 5 (The St. Louis Cardinals selected RHP Benito Garcia in the Rule 5 Draft.) |
| | 3B | Drafted Via Rule 5 (The St. Louis Cardinals selected INF Johnfrank Salazar in the Rule 5 Draft.) |
| | SS | Drafted Via Rule 5 (The St. Louis Cardinals selected INF Miguel Villarroel in the Rule 5 Draft.) |
| | P | Drafted Via Rule 5 (The St. Louis Cardinals selected RHP Ryan Fernandez in the Rule 5 Draft.) |
| | P | Signed (The St. Louis Cardinals signed RHP Sonny Gray.) |
| | P | Non-roster Invitee (The St. Louis Cardinals signed RHP Wilking Rodríguez to a minor league contract with an invitation to spring training.) |
| | P | Signed (The St. Louis Cardinals signed RHP Kyle Gibson.) |
| | P | Signed (The St. Louis Cardinals signed RHP Lance Lynn.) |
| | P | Released (The St. Louis Cardinals released RHP Dakota Hudson.) |
| | P | Released (The St. Louis Cardinals released RHP Jake Woodford.) |
| | LF | Released (The St. Louis Cardinals released OF Juan Yepez.) |
| | C | Released (The St. Louis Cardinals released C Andrew Knizner.) |
| | P | Sent to Minors (The St. Louis Cardinals sent LHP Connor Thomas outright to the minors.) |
| | P | Declared Free Agency (RHP Wilking Rodríguez declared free agency.) |
| | P | Designated for Assignment (The St. Louis Cardinals designated LHP Connor Thomas for assignment.) |
| | P | Sent to Minors (The St. Louis Cardinals sent LHP Packy Naughton outright to the minors.) |
| | P | Activated (The St. Louis Cardinals selected the contract of RHP Sem Robberse from the minors.) |
| | C | Activated (The St. Louis Cardinals selected the contract of C Pedro Pagés from the minors.) |
| | P | Activated (The St. Louis Cardinals selected the contract of RHP Adam Kloffenstein from the minors.) |
| | P | Sent to Minors (The St. Louis Cardinals sent RHP Wilking Rodríguez outright to the minors.) |
| | P | Declared Free Agency (RHP Jose Martinez declared free agency.) |
| | 2B | Declared Free Agency (INF Irving Lopez declared free agency.) |
| | P | Traded (The Seattle Mariners traded RHP Riley O'Brien to the St. Louis Cardinals.) From |
| | 1B | Claimed on Unconditional Release Waivers (The St. Louis Cardinals claimed INF Jared Young off waivers from the Chicago Cubs.) |
| | P | Activated (The St. Louis Cardinals activated LHP Steven Matz.) |
| | P | Activated (The St. Louis Cardinals activated RHP Jake Woodford.) |
| | P | Activated (The St. Louis Cardinals activated RHP Giovanny Gallegos.) |
| | P | Activated (The St. Louis Cardinals activated RHP Wilking Rodríguez from the 60-day injured list.) |
| | LF | Activated (The St. Louis Cardinals activated INF Brendan Donovan from the 60-day injured list.) |
| | 3B | Activated (The St. Louis Cardinals activated INF Nolan Arenado.) |
| | P | Activated (The St. Louis Cardinals activated LHP Packy Naughton from the 60-day injured list.) |
| | LF | Activated (The St. Louis Cardinals activated OF Moisés Gómez.) |
| | P | Activated (The St. Louis Cardinals activated RHP Guillermo Zuñiga from the 60-day injured list.) |
| | C | Activated (The St. Louis Cardinals activated C Willson Contreras.) |
| | RF | Activated (The St. Louis Cardinals activated OF Dylan Carlson from the 60-day injured list.) |
| | 2B | Activated (The St. Louis Cardinals activated INF Nolan Gorman.) |
| | 2B | Activated (The St. Louis Cardinals activated INF Buddy Kennedy.) |
| | LF | Activated (The St. Louis Cardinals activated OF Tyler O'Neill.) |
| | RF | Activated (The St. Louis Cardinals activated OF Alec Burleson.) |
| | P | Activated (The St. Louis Cardinals activated LHP JoJo Romero.) |
| | P | Activated (The St. Louis Cardinals activated LHP Connor Thomas.) |