| | P | Traded (The San Diego Padres traded RHP Nick Hernandez to the Houston Astros for cash.) To |
| | P | Starting to Serve Suspension (Major League Baseball suspended San Diego Padres' LHP Jay Groome for violations of MLB's sports betting policy.) |
| | SS | Starting to Serve Suspension (Major League Baseball suspended San Diego Padres' INF Tucupita Marcano for violations of MLB's sports betting policy.) |
| | P | Recalled From Minors Rehab (The San Diego Padres selected the contract of SP Adam Mazur.) |
| | P | Sent to Minors (The San Diego Padres optioned RP Logan Gillaspie to the minors.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RHP Logan Gillaspie from the minors.) |
| | P | Placed on 15-Day IL (The San Diego Padres placed RHP Joe Musgrove on the 15-day injured list with an elbow injury.) |
| | P | Placed on 15-Day IL (The San Diego Padres placed RHP Yu Darvish on the 15-day injured list with a groin strain.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RHP Randy Vásquez from the minors.) |
| | 2B | Placed on 10-Day IL (The San Diego Padres placed INF Xander Bogaerts on the 10-day injured list.) |
| | RF | Recalled From Minors Rehab (The San Diego Padres selected the contract of OF David Peralta from the minors.) |
| | P | Placed on 60-Day IL (The San Diego Padres transferred RHP Luis Patino to the 60-day injured list.) |
| | P | Sent to Minors (The San Diego Padres optioned SP Randy Vasquez to the minors.) |
| | P | Activated (The San Diego Padres activated RHP Joe Musgrove from 15-Day IL.) |
| | P | Sent to Minors (The San Diego Padres returned RP Logan Gillaspie to the minors.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RHP Logan Gillaspie from the minors. He will serve as the teams' 27th player in its doubleheader against the Braves. ) |
| | RF | Signed (The San Diego Padres signed OF David Peralta to a minor league contract.) |
| | P | Released (The San Diego Padres released RHP Matt Festa.) |
| | P | Placed on 15-Day IL (The San Diego Padres placed SP Joe Musgrove on the 15-day injured list.) |
| | 3B | Recalled From Minors Rehab (The San Diego Padres selected the contract of INF Donovan Solano.) |
| | 3B | Sent to Minors (The San Diego Padres optioned INF Eguy Rosario to the minors.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled SP Randy Vasquez from the minors.) |
| | 2B | Activated (The San Diego Padres recalled INF Luis Arraez from the minors.) |
| | 3B | Sent to Minors (The San Diego Padres optioned INF Graham Pauley to the minors.) |
| | 2B | Traded (The Miami Marlins traded INF Luis Arraez to the San Diego Padres.) From |
| | CF | Traded (The San Diego Padres traded OF Jakob Marsee to the Miami Marlins.) To |
| | 1B | Traded (The San Diego Padres traded INF Nathan Martorella to the Miami Marlins.) To |
| | P | Traded (The San Diego Padres traded RHP Woo-Suk Go to the Miami Marlins.) To |
| | CF | Traded (The San Diego Padres traded OF Dillon Head to the Miami Marlins.) To |
| | P | Sent to Minors (The San Diego Padres optioned RP Tom Cosgrove to the minors.) |
| | P | Activated (The San Diego Padres activated RHP Yu Darvish from the 15-day injured list.) |
| | P | Sent to Minors (The San Diego Padres optioned SP Randy Vasquez to the minors.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RP Jeremiah Estrada from the minors.) |
| | 1B | Sent to Minors (The San Diego Padres optioned INF Matthew Batten to the minors.) |
| | 3B | Activated (The San Diego Padres activated DH Manny Machado off the Paternity List.) |
| | 1B | Recalled From Minors Rehab (The San Diego Padres recalled INF Matthew Batten from the minors.) |
| | 3B | Placed on Paternity Leave List (The San Diego Padres placed DH Manny Machado on the Paternity Leave list.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RHP Randy Vásquez from the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Logan Gillaspie to the minors.) |
| | 1B | Sent to Minors (The San Diego Padres optioned INF Matthew Batten to the minors.) |
| | 3B | Recalled From Minors Rehab (The San Diego Padres recalled INF Graham Pauley from the minors.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RHP Logan Gillaspie from the minors.) |
| | P | Traded (The San Diego Padres traded RHP Pedro Avila to the Cleveland Guardians.) To |
| | P | Placed on 15-Day IL (The San Diego Padres placed RHP Yu Darvish on the 15-day injured list.) |
| | 1B | Sent to Minors (The San Diego Padres optioned C Brett Sullivan to the minors.) |
| | 1B | Recalled From Minors Rehab (The San Diego Padres recalled INF Matthew Batten from the minors.) |
| | 3B | Signed (The San Diego Padres signed INF Donovan Solano to a minor league contract.) |
| | 3B | Signed (The San Diego Padres signed INF Donovan Solano to a minor league contract.) |
| | P | Designated for Assignment (The San Diego Padres designated RP Pedro Avila for assignment.) |
| | P | Recalled From Minors Rehab (The San Diego Padres recalled RP Adrian Morejon from the minors.) |
| | 3B | Sent to Minors (The San Diego Padres optioned INF Graham Pauley to the minors.) |
| | 1B | Recalled From Minors Rehab (The San Diego Padres recalled C Brett Sullivan from the minors.) |
| | | Traded (The San Diego Padres traded SS Kervin Pichardo to the Pittsburgh Pirates.) To |
| | P | Traded (The Pittsburgh Pirates traded LHP Jackson Wolf to the San Diego Padres.) From |
| | P | Sent to Minors (The San Diego Padres optioned LHP Adrian Morejon to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Randy Vásquez to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Jeremiah Estrada to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Woo-Suk Go to the minors.) |
| | 3B | Recalled From Minors Rehab (The San Diego Padres selected the contract of INF Tyler Wade from the minors.) |
| | CF | Recalled From Minors Rehab (The San Diego Padres selected the contract of INF Jackson Merrill from the minors.) |
| | 1B | Sent to Minors (The San Diego Padres optioned C Brett Sullivan to the minors.) |
| | P | Placed on 15-Day IL (The San Diego Padres placed RHP Glenn Otto on the 15-day injured list.) |
| | SS | Placed on 10-Day IL (The San Diego Padres placed INF Tucupita Marcano on the 10-day injured list.) |
| | P | Placed on 15-Day IL (The San Diego Padres placed RHP Luis Patiño on the 15-day injured list.) |
| | 3B | Recalled From Minors Rehab (The San Diego Padres selected the contract of INF Graham Pauley from the minors.) |
| | CF | Traded (The San Diego Padres traded OF Samuel Zavala to the Chicago White Sox.) To |
| | P | Traded (The Chicago White Sox traded RHP Dylan Cease to the San Diego Padres.) From |
| | P | Traded (The San Diego Padres traded RHP Steven Wilson to the Chicago White Sox.) To |
| | P | Traded (The San Diego Padres traded RHP Drew Thorpe to the Chicago White Sox.) To |
| | P | Traded (The San Diego Padres traded RHP Jairo Iriarte to the Chicago White Sox.) To |
| | RF | Sent to Minors (The San Diego Padres sent OF Cal Mitchell to the minors.) |
| | 1B | Sent to Minors (The San Diego Padres optioned INF Matthew Batten to the minors.) |
| | C | Sent to Minors (The San Diego Padres sent C Kevin Plawecki to the minors.) |
| | CF | Sent to Minors (The San Diego Padres sent OF Jakob Marsee to the minors.) |
| | LF | Sent to Minors (The San Diego Padres sent OF Tim Locastro to the minors.) |
| | SS | Sent to Minors (The San Diego Padres sent INF Mason McCoy to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Logan Gillaspie to the minors.) |
| | P | Sent to Minors (The San Diego Padres assigned RHP Tommy Nance to minor league camp.) |
| | P | Sent to Minors (The San Diego Padres assigned RHP Ryan Bergert to minor league camp.) |
| | P | Sent to Minors (The San Diego Padres assigned LHP Jayvien Sandridge to minor league camp.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Alek Jacob to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Adam Mazur to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent LHP Austin Krob to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Nick Hernandez to the minors.) |
| | SS | Sent to Minors (The San Diego Padres sent INF Marcos Castañon to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Jairo Iriarte to the minors.) |
| | C | Sent to Minors (The San Diego Padres sent C Ethan Salas to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent LHP Daniel Camarena to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent LHP Robby Snelling to the minors.) |
| | 2B | Non-roster Invitee (The San Diego Padres signed DH Brad Miller to a minor league contract with an invitation to spring training.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Jairo Iriarte to the minors.) |
| | CF | Sent to Minors (The San Diego Padres sent OF Bryce Johnson to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Matt Festa to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent LHP Ryan Carpenter to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned RHP Sean Reynolds to the minors.) |
| | P | Sent to Minors (The San Diego Padres optioned LHP Jay Groome to the minors.) |
| | P | Signed (The San Diego Padres signed LHP Paul Fry to a minor league contract.) |
| | P | Signed (The San Diego Padres signed LHP Paul Fry to a minor league contract.) |
| | CF | Sent to Minors (The San Diego Padres sent OF Tirso Ornelas to the minors.) |
| | 2B | Sent to Minors (The San Diego Padres sent INF Nate Mondou to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Lake Bachar to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Kevin Kopps to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Drew Carlton to the minors.) |
| | C | Sent to Minors (The San Diego Padres sent C Chandler Seagle to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Yovanny Cruz to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Nolan Watson to the minors.) |
| | RF | Sent to Minors (The San Diego Padres sent OF Robert Perez Jr. to the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Moises Lugo to the minors.) |
| | | Signed (The San Diego Padres signed RHP Humberto Cruz.) |
| | | Signed (The San Diego Padres signed RHP Humberto Cruz.) |
| | P | Traded (The San Diego Padres traded LHP Blake Dickerson to the Detroit Tigers.) To |
| | | Traded (The San Diego Padres traded OF Oliver Carrillo to the Houston Astros.) To |
| | LF | Signed (The San Diego Padres signed OF Jurickson Profar.) |
| | P | Signed (The San Diego Padres signed LHP Mitch Miller to a minor league contract.) |
| | LF | Signed (The San Diego Padres signed OF Zach Reks to a minor league contract.) |
| | LF | Signed (The San Diego Padres signed OF Zach Reks to a minor league contract.) |
| | P | Signed (The San Diego Padres signed LHP Austin Davis to a minor league contract.) |
| | P | Signed (The San Diego Padres signed LHP Austin Davis to a minor league contract.) |
| | P | Signed (The San Diego Padres signed LHP Wandy Peralta.) |
| | P | Signed (The San Diego Padres signed RHP Josh Roberson to a minor league contract.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Tommy Nance to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Kevin Kopps to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited LHP Jayvien Sandridge to spring training.) |
| | 2B | Non-roster Invitee (The San Diego Padres invited INF Nate Mondou to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres signed RHP Nick Hernandez to a minor league contract with an invitation to spring training.) |
| | CF | Non-roster Invitee (The San Diego Padres invited INF Jackson Merrill to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Nolan Watson to spring training.) |
| | C | Non-roster Invitee (The San Diego Padres invited C Ethan Salas to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres signed RHP Matt Festa to a minor league contract with an invitation to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited LHP Robby Snelling to spring training.) |
| | CF | Non-roster Invitee (The San Diego Padres invited OF Tirso Ornelas to spring training.) |
| | 3B | Non-roster Invitee (The San Diego Padres invited INF Tyler Wade to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited LHP Austin Krob to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Drew Thorpe to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Yovanny Cruz to spring training.) |
| | RF | Non-roster Invitee (The San Diego Padres invited INF Robert Perez to spring training.) |
| | SS | Non-roster Invitee (The San Diego Padres invited INF Marcos Castañon to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Ryan Bergert to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Adam Mazur to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited LHP Ryan Carpenter to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Moises Lugo to spring training.) |
| | RF | Non-roster Invitee (The San Diego Padres invited OF Óscar Mercado to spring training.) |
| | 3B | Non-roster Invitee (The San Diego Padres invited INF Graham Pauley to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited RHP Drew Carlton to spring training.) |
| | P | Non-roster Invitee (The San Diego Padres invited LHP Daniel Camarena to spring training.) |
| | C | Non-roster Invitee (The San Diego Padres invited C Chandler Seagle to spring training.) |
| | CF | Non-roster Invitee (The San Diego Padres invited OF Jakob Marsee to spring training.) |
| | C | Non-roster Invitee (The San Diego Padres invited C Kevin Plawecki to spring training.) |
| | C | Signed (The San Diego Padres signed C Chandler Seagle to a minor league contract.) |
| | P | Signed (The San Diego Padres signed LHP Daniel Camarena to a minor league contract.) |
| | RF | Signed (The San Diego Padres signed OF Óscar Mercado to a minor league contract.) |
| | CF | Non-roster Invitee (The San Diego Padres signed OF Bryce Johnson to a minor league contract with an invitation to spring training.) |
| | P | Signed (The San Diego Padres signed RHP Woo Suk Go.) |
| | C | Signed (The San Diego Padres signed C Kevin Plawecki to a minor league contract.) |
| | C | Signed (The San Diego Padres signed C Michael De La Cruz to a minor league contract.) |
| | P | Signed (The San Diego Padres signed RHP Tommy Nance.) |
| | 2B | Signed (The San Diego Padres signed INF Nate Mondou to a minor league contract.) |
| | P | Drafted Via Rule 5 (The San Diego Padres selected RHP Stephen Kolek in the Rule 5 Draft.) |
| | P | Traded (The New York Yankees traded RHP Jhony Brito to the San Diego Padres.) From |
| | P | Drafted Via Rule 5 (The San Diego Padres selected LHP Omar Cruz in the Rule 5 Draft.) |
| | RF | Traded (The San Diego Padres traded OF Juan Soto to the New York Yankees.) To |
| | P | Traded (The New York Yankees traded RHP Michael King to the San Diego Padres.) From |
| | CF | Traded (The San Diego Padres traded OF Trent Grisham to the New York Yankees.) To |
| | SS | Drafted Via Rule 5 (The San Diego Padres selected INF Clay Dungan in the Rule 5 Draft.) |
| | P | Traded (The New York Yankees traded RHP Drew Thorpe to the San Diego Padres.) From |
| | P | Traded (The New York Yankees traded RHP Randy Vásquez to the San Diego Padres.) From |
| | C | Traded (The New York Yankees traded C Kyle Higashioka to the San Diego Padres.) From |
| | CF | Released (The San Diego Padres released OF Taylor Kohlwey.) |
| | RF | Signed (The San Diego Padres signed INF Robert Perez to a minor league contract.) |
| | P | Traded (The San Diego Padres traded RHP Scott Barlow to the Cleveland Guardians.) To |
| | P | Released (The San Diego Padres released LHP Tim Hill.) |
| | P | Signed (The San Diego Padres signed RHP Yovanny Cruz to a minor league contract.) |
| | C | Released (The San Diego Padres released C Austin Nola.) |
| | P | Traded (The Cleveland Guardians traded RHP Enyel De Los Santos to the San Diego Padres.) From |
| | P | Released (The San Diego Padres released RHP Jose Espada.) |
| | P | Claimed on Unconditional Release Waivers (The San Diego Padres claimed RHP Logan Gillaspie off waivers from the Boston Red Sox.) |
| | P | Recalled From Minors Rehab (The San Diego Padres selected the contract of RHP Jairo Iriarte from the minors.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Reiss Knehr outright to the minors.) |
| | 3B | Signed (The San Diego Padres signed INF Tyler Wade to a minor league contract.) |
| | CF | Released (The San Diego Padres released OF Eddy Beltre.) |
| | P | Signed (The San Diego Padres signed RHP Drew Carlton to a minor league contract.) |
| | 2B | Declared Free Agency (INF Tim Lopes declared free agency.) |
| | P | Declared Free Agency (RHP Edwuin Bencomo declared free agency.) |
| | P | Declared Free Agency (RHP Henry Henry declared free agency.) |
| | P | Declared Free Agency (LHP CD Pelham declared free agency.) |
| | P | Declared Free Agency (RHP Lake Bachar declared free agency.) |
| | C | Declared Free Agency (C Michael Cantu declared free agency.) |
| | RF | Declared Free Agency (OF Daniel Johnson declared free agency.) |
| | CF | Declared Free Agency (OF Luis Liberato declared free agency.) |
| | C | Declared Free Agency (C Chandler Seagle declared free agency.) |
| | P | Declared Free Agency (RHP Efraín Contreras declared free agency.) |
| | P | Declared Free Agency (LHP Aaron Leasher declared free agency.) |
| | P | Declared Free Agency (RHP Jake Sanchez declared free agency.) |
| | P | Declared Free Agency (RHP Drew Carlton declared free agency.) |
| | 3B | Declared Free Agency (INF Jantzen Witte declared free agency.) |
| | P | Declared Free Agency (RHP Anderson Espinoza declared free agency.) |
| | C | Declared Free Agency (C Juan Fernandez declared free agency.) |
| | RF | Declared Free Agency (OF Max Schrock declared free agency.) |
| | P | Declared Free Agency (RHP Sean Poppen declared free agency.) |
| | P | Declared Free Agency (LHP Jared Koenig declared free agency.) |
| | P | Declared Free Agency (LHP Brian Gonzalez declared free agency.) |
| | P | Declared Free Agency (RHP Eric Hanhold declared free agency.) |
| | P | Declared Free Agency (RHP Angel Sanchez declared free agency.) |
| | P | Declared Free Agency (RHP Wilmer Font declared free agency.) |
| | 3B | Declared Free Agency (INF Evan Mendoza declared free agency.) |
| | C | Declared Free Agency (C Michael De La Cruz declared free agency.) |
| | P | Declared Free Agency (RHP Aaron Brooks declared free agency.) |
| | SS | Declared Free Agency (INF Justin Lopez declared free agency.) |
| | P | Declared Free Agency (LHP Daniel Camarena declared free agency.) |
| | 1B | Declared Free Agency (INF Rangel Ravelo declared free agency.) |
| | P | Declared Free Agency (LHP Noel Vela declared free agency.) |
| | P | Declared Free Agency (RHP Nick Hernandez declared free agency.) |
| | P | Claimed on Unconditional Release Waivers (The San Diego Padres claimed RHP Jeremiah Estrada off waivers from the Chicago Cubs.) |
| | P | Sent to Minors (The San Diego Padres sent RHP Nick Hernandez outright to the minors.) |
| | P | Declared Free Agency (The San Diego Padres RHP Michael Wacha declared free agency.) |
| | P | Declared Free Agency (The San Diego Padres RHP Nick Martinez declared free agency.) |
| | P | Designated for Assignment (The San Diego Padres designated RHP Nick Hernandez for assignment.) |
| | C | Sent to Minors (The San Diego Padres sent C Chandler Seagle outright to the minors.) |