| | P | Activated (The Chicago Cubs activated LHP Drew Smyly from the 15-day injured list.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP José Cuas to the minors.) |
| | P | Signed (The Chicago Cubs signed RHP Jackson Tetreault to a minor league contract.) |
| | SS | Activated (The Chicago Cubs activated INF Dansby Swanson from the 10-day injured list.) |
| | SS | Recalled From Minors Rehab (The Chicago Cubs recalled INF Luis Vázquez from the minors.) |
| | CF | Sent to Minors (The Chicago Cubs optioned OF Pete Crow-Armstrong to the minors.) |
| | SS | Sent to Minors (The Chicago Cubs optioned INF Miles Mastrobuoni to the minors.) |
| | P | Traded (The Chicago Cubs traded LHP Richard Lovelady to the Tampa Bay Rays.) To |
| | P | Traded (The Tampa Bay Rays traded LHP Jeff Belge to the Chicago Cubs.) From |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RHP Colten Brewer on the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP Porter Hodge from the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled LHP Luke Little from the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RHP Keegan Thompson on the 15-day injured list.) |
| | P | Traded (The Seattle Mariners traded RHP Tyson Miller to the Chicago Cubs.) From |
| | 3B | Traded (The Chicago Cubs traded INF Jake Slaughter to the Seattle Mariners.) To |
| | C | Free Agent - No Contract Offer (C Curt Casali opted out of his minor league contract with the Chicago Cubs.) |
| | P | Designated for Assignment (The Chicago Cubs designated LHP Richard Lovelady for assignment.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RHP Adbert Alzolay on the 15-day injured list with a forearm strain.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP José Cuas from the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP José Cuas to the minors.) |
| | P | Activated (The Chicago Cubs activated RHP Kyle Hendricks from the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP José Cuas from the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RHP Yency Almonte on the 15-day injured list with a shoulder injury.) |
| | RF | Activated (The Chicago Cubs activated OF Seiya Suzuki from the 10-day injured list.) |
| | RF | Signed Contract Extension (Chicago Cubs OF David Peralta opted out of his minor league contract and became a free agent.) |
| | SS | Placed on 10-Day IL (The Chicago Cubs placed INF Dansby Swanson on the 10-day injured list.) |
| | LF | Sent to Minors (The Chicago Cubs optioned OF Alexander Canario to the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RP Daniel Palencia on the 15-day injured list.) |
| | CF | Activated (The Chicago Cubs activated OF Cody Bellinger from the 10-day injured list.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RP Keegan Thompson from the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Keegan Thompson to the minors.) |
| | P | Activated (The Chicago Cubs activated LHP Justin Steele from the 15-day injured list.) |
| | SS | Recalled From Minors Rehab (The Chicago Cubs recalled INF Miles Mastrobuoni from the minors.) |
| | 1B | Sent to Minors (The Chicago Cubs optioned INF Matt Mervis to the minors.) |
| | | Signed (The Chicago Cubs signed P Roque Osorio to a minor league contract.) |
| | | Signed (The Chicago Cubs signed P Roque Osorio to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed free agent RHP Dan Straily to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed free agent RHP Dan Straily to a minor league contract.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed LHP Jordan Wicks on the 15-day injured list with a forearm strain.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs selected the contract LHP Richard Lovelady from the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP Daniel Palencia from the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned LHP Luke Little to the minors.) |
| | 1B | Traded (The Chicago Cubs traded INF Garrett Cooper to the Boston Red Sox.) To |
| | CF | Placed on 10-Day IL (The Chicago Cubs placed OF Cody Bellinger on the 10-day injured list.) |
| | CF | Recalled From Minors Rehab (The Chicago Cubs recalled OF Pete Crow-Armstrong from the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed SP Kyle Hendricks on the 15-day injured list.) |
| | 1B | Recalled From Minors Rehab (The Chicago Cubs recalled INF Matt Mervis from the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RP Drew Smyly on the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RP Luke Little from the minors.) |
| | 1B | Designated for Assignment (The Chicago Cubs designated INF Garrett Cooper for assignment.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RP Hayden Wesneski from the minors.) |
| | P | Signed (The Chicago Cubs signed LHP Mitchell Tyranski to a minor league contract.) |
| | P | Sent to Minors (The Chicago Cubs optioned LHP Luke Little to the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled LHP Luke Little from the minors.) |
| | P | Signed (The Chicago Cubs signed RHP Julio Teheran to a minor league contract.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Hayden Wesneski to the minors.) |
| | P | Signed (The Chicago Cubs signed RHP Julio Teheran to a minor league contract.) |
| | 1B | Activated (The Chicago Cubs activated INF Patrick Wisdom from the 10-day injured list.) |
| | SS | Sent to Minors (The Chicago Cubs optioned INF Miles Mastrobuoni to the minors.) |
| | P | Activated (The Chicago Cubs activated RHP Jameson Taillon from the 15-day injured list.) |
| | P | Sent to Minors (The Chicago Cubs optioned LHP Luke Little to the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs selected the contract of RHP Colten Brewer from the minors.) |
| | P | Placed on 60-Day IL (The Chicago Cubs placed RP Julian Merryweather on the 60-Day injured list ) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Daniel Palencia to the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP Hayden Wesneski from the minors.) |
| | LF | Recalled From Minors Rehab (The Chicago Cubs recalled OF Alexander Canario from the minors.) |
| | RF | Placed on 10-Day IL (The Chicago Cubs placed OF Seiya Suzuki on the 10-day injured list with an oblique strain.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP José Cuas to the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RP Keegan Thompson from the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RP Daniel Palencia from the minors.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RP Julian Merryweather on the 15-Day Injury List with a right shoulder strain.) |
| | P | Signed (The Chicago Cubs signed RHP Carl Edwards to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed RHP Carl Edwards to a minor league contract.) |
| | C | Signed (The Chicago Cubs signed C Alí Sánchez to a minor league contract.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed LHP Justin Steele on the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs recalled RHP Ben Brown from the minors.) |
| | C | Signed (The Chicago Cubs signed C Curt Casali to a minor league contract.) |
| | C | Signed (The Chicago Cubs signed C Curt Casali to a minor league contract.) |
| | 1B | Placed on 10-Day IL (The Chicago Cubs placed INF Patrick Wisdom on the 10-day injured list.) |
| | P | Placed on 15-Day IL (The Chicago Cubs placed RHP Jameson Taillon on the 15-day injured list.) |
| | P | Placed on 60-Day IL (The Chicago Cubs placed RHP Caleb Kilian on the 60-day injured list.) |
| | 1B | Recalled From Minors Rehab (The Chicago Cubs selected the contract of INF Garrett Cooper from the minors.) |
| | C | Sent to Minors (The Chicago Cubs sent C Joe Hudson to the minors.) |
| | C | Released (The Chicago Cubs released C Jorge Alfaro.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Hayden Wesneski to the minors.) |
| | LF | Sent to Minors (The Chicago Cubs optioned OF Alexander Canario to the minors.) |
| | P | Declared Free Agency (RHP Carl Edwards opted out of his contract with the Chicago Cubs and became a free agent.) |
| | P | Sent to Minors (The Chicago Cubs sent LHP Edwin Escobar to the minors.) |
| | 1B | Declared Free Agency (INF Dominic Smith elected free agency.) |
| | P | Sent to Minors (The Chicago Cubs sent LHP Richard Lovelady to the minors.) |
| | 2B | Sent to Minors (The Chicago Cubs sent INF David Bote to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Colten Brewer to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent LHP Thomas Pannone to the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Daniel Palencia to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Cam Sanders to the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Keegan Thompson to the minors.) |
| | 1B | Sent to Minors (The Chicago Cubs optioned INF Matt Mervis to the minors.) |
| | 2B | Sent to Minors (The Chicago Cubs sent INF Chase Strumpf to the minors.) |
| | C | Sent to Minors (The Chicago Cubs sent C Bryce Windham to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent LHP Brad Wieck to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Sam McWilliams to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Chris Clarke to the minors.) |
| | SS | Sent to Minors (The Chicago Cubs sent INF Matt Shaw to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Ethan Roberts to the minors.) |
| | SS | Sent to Minors (The Chicago Cubs optioned INF Luis Vazquez to the minors.) |
| | CF | Sent to Minors (The Chicago Cubs optioned OF Pete Crow-Armstrong to the minors.) |
| | CF | Sent to Minors (The Chicago Cubs optioned OF Brennen Davis to the minors.) |
| | CF | Sent to Minors (The Chicago Cubs optioned OF Kevin Alcántara to the minors.) |
| | C | Sent to Minors (The Chicago Cubs sent C Pablo Aliendo to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Riley Thompson to the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Porter Hodge to the minors.) |
| | CF | Sent to Minors (The Chicago Cubs sent OF Owen Caissie to the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Ben Brown to the minors.) |
| | P | Sent to Minors (The Chicago Cubs optioned RHP Michael Arias to the minors.) |
| | P | Traded (The Chicago White Sox traded RHP Matthew Thompson to the Chicago Cubs.) From |
| | P | Traded (The Chicago Cubs traded LHP Bailey Horn to the Chicago White Sox.) To |
| | RF | Non-roster Invitee (The Chicago Cubs signed OF David Peralta to a minor league contract with an invitation to spring training.) |
| | C | Non-roster Invitee (The Chicago Cubs invited C Bryce Windham to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited RHP Ethan Roberts to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited RHP Sam McWilliams to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited RHP Cam Sanders to spring training.) |
| | 2B | Non-roster Invitee (The Chicago Cubs invited INF David Bote to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited RHP Chris Clarke to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited RHP Riley Thompson to spring training.) |
| | 2B | Non-roster Invitee (The Chicago Cubs invited INF Chase Strumpf to spring training.) |
| | SS | Non-roster Invitee (The Chicago Cubs invited INF Matt Shaw to spring training.) |
| | CF | Non-roster Invitee (The Chicago Cubs invited OF Owen Caissie to spring training.) |
| | C | Non-roster Invitee (The Chicago Cubs invited C Pablo Aliendo to spring training.) |
| | P | Non-roster Invitee (The Chicago Cubs invited LHP Brad Wieck to spring training.) |
| | P | Traded (The Chicago Cubs traded RHP Michael Rucker to the Philadelphia Phillies.) To |
| | P | Signed (The Chicago Cubs signed LHP Blake Weiman to a minor league contract.) |
| | P | Designated for Assignment (The Chicago Cubs designated RHP Michael Rucker for assignment.) |
| | P | Signed (The Chicago Cubs signed RHP Sam McWilliams to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed RHP Hector Neris.) |
| | P | Non-roster Invitee (The Chicago Cubs signed RHP Carl Edwards to a minor league contract with an invitation to spring training.) |
| | C | Designated for Assignment (The Chicago Cubs designated C Brian Serven for assignment.) |
| | P | Traded (The Chicago Cubs traded LHP Jackson Ferris to the Los Angeles Dodgers.) To |
| | CF | Traded (The Chicago Cubs traded OF Zyhir Hope to the Los Angeles Dodgers.) To |
| | 1B | Traded (The Los Angeles Dodgers traded INF Michael Busch to the Chicago Cubs.) From |
| | P | Traded (The Los Angeles Dodgers traded RHP Yency Almonte to the Chicago Cubs.) From |
| | P | Signed (The Chicago Cubs signed LHP Shota Imanaga.) |
| | P | Non-roster Invitee (The Chicago Cubs invited non-roster RHP Colten Brewer to spring training.) |
| | C | Claimed on Unconditional Release Waivers (The Chicago Cubs claimed C Brian Serven off waivers from the Colorado Rockies.) |
| | P | Signed (The Chicago Cubs signed RHP Colten Brewer to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed RHP Colten Brewer to a minor league contract.) |
| | P | Signed (The Chicago Cubs signed RHP Ethan Roberts to a minor league contract.) |
| | SS | Drafted Via Rule 5 (The Chicago Cubs selected INF Hayden Cantrelle in the Rule 5 Draft.) |
| | P | Declared Free Agency (LHP Brailyn Marquez declared free agency.) |
| | P | Non-roster Invitee (The Chicago Cubs signed LHP Edwin Escobar to a minor league contract with an invitation to spring training.) |
| | P | Released (The Chicago Cubs released RHP Ethan Roberts.) |
| | P | Declared Free Agency (LHP Brandon Hughes declared free agency.) |
| | P | Released (The Chicago Cubs released RHP Codi Heuer.) |
| | P | Released (The Chicago Cubs released LHP Brandon Hughes.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs selected the contract of RHP Michael Arias from the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs selected the contract of LHP Bailey Horn from the minors.) |
| | P | Recalled From Minors Rehab (The Chicago Cubs selected the contract of RHP Porter Hodge from the minors.) |
| | P | Declared Free Agency (RHP Yovanny Cruz elected free agency.) |
| | P | Declared Free Agency (LHP Brailyn Marquez elected free agency.) |
| | P | Declared Free Agency (RHP Nick Neidert elected free agency.) |
| | P | Declared Free Agency (RHP Ben Hecht elected free agency.) |
| | P | Declared Free Agency (RHP Samuel Reyes elected free agency.) |
| | P | Declared Free Agency (RHP Nick Burdi elected free agency.) |
| | 2B | Declared Free Agency (INF Yonathan Perlaza elected free agency.) |
| | P | Declared Free Agency (LHP Stephen Gonsalves declared free agency.) |
| | P | Declared Free Agency (RHP Carlos Guzman declared free agency.) |
| | SS | Recalled From Minors Rehab (The Chicago Cubs selected the contract of INF Luis Vazquez from the minors.) |
| | P | Released (The Chicago Cubs released RHP Michael McAvene.) |
| | P | Released (The Chicago Cubs released LHP Scott Kobos.) |
| | P | Declared Free Agency (RHP Marcus Stroman elected free agency.) |
| | CF | Declared Free Agency (The Chicago Cubs INF Cody Bellinger declared free agency.) |
| | P | Declared Free Agency (The Chicago Cubs RHP Brad Boxberger declared free agency.) |
| | P | Activated (The Chicago Cubs activated RHP Ethan Roberts.) |
| | P | Activated (The Chicago Cubs activated LHP Brandon Hughes.) |
| | 3B | Activated (The Chicago Cubs activated INF Nick Madrigal from the 60-day injured list.) |
| | P | Activated (The Chicago Cubs activated RHP Codi Heuer.) |
| | 1B | Activated (The Chicago Cubs activated INF Matt Mervis.) |
| | P | Activated (The Chicago Cubs activated RHP Keegan Thompson.) |
| | P | Activated (The Chicago Cubs activated RHP Ben Brown.) |
| | P | Activated (The Chicago Cubs activated RHP Hayden Wesneski.) |
| | P | Activated (The Chicago Cubs activated RHP Brad Boxberger.) |
| | P | Activated (The Chicago Cubs activated RHP Michael Rucker.) |
| | P | Activated (The Chicago Cubs activated RHP Caleb Kilian.) |
| | 2B | Activated (The Chicago Cubs activated INF Nico Hoerner.) |
| | CF | Activated (The Chicago Cubs activated OF Kevin Alcántara.) |
| | CF | Activated (The Chicago Cubs activated OF Brennen Davis.) |
| | P | Activated (The Chicago Cubs activated LHP Jordan Wicks.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Nick Burdi outright to the minors.) |
| | P | Sent to Minors (The Chicago Cubs sent RHP Jeremiah Estrada outright to the minors.) |
| | P | Declared Free Agency (Chicago Cubs RHP Shane Greene declared free agency.) |
| | P | Declared Free Agency (Chicago Cubs RHP Michael Fulmer declared free agency.) |
| | 1B | Sent to Minors (The Chicago Cubs sent INF Jared Young outright to the minors.) |
| | 3B | Declared Free Agency (Chicago Cubs INF Jeimer Candelario declared free agency.) |
| | P | Declared Free Agency (RHP Tyler Duffey declared free agency.) |